Category: 6. Health

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Crucial warning signs in the blood of Alzheimer’s disease occur more in over-85s and less in under-75s than previously…

Dementia is a growing global challenge, with Alzheimer’s disease (AD) being the most common cause, characterized by ADNCs, encompassing brain deposits of amyloid-β (Aβ) plaque and neurofibrillary tau tangles. The prevalence of dementia and…

Animals

All animal experiments were approved by the Salk Institute Institutional Animal Care and Use Committee (IACUC). Rats and mice were typically housed with a standard 12 h:12 h light:dark cycle in the Salk Institute animal facilities,…

Mice

Young adult male and female mice were used between 2 and 4 months of age at the time of experimental procedures. C57BL/6 J mice (JAX: 000664) were used for experiments requiring a wild-type background. For RNA-seq of astrocyte-specific…

Ethical statement

All experiments were performed in compliance with all relevant ethical regulations as approved by the Institutional Biosafety Committee (IBC) of the Broad Institute (protocol #IBC-2017-00146). All animal experiments were approved…

Human specimens

All human liver tissues used in this study were obtained after informed consent was obtained from patients undergoing operations at either the Department of Visceral, Thoracic and Vascular Surgery (VTG), University Hospital Carl…