Researchers with OHSU’s Neuro-Oncology Blood-Brain Barrier Program supported several clinical trials investigating a novel use of a drug for brain cancer imaging; the data helped achieve its recent FDA-approval. (OHSU/Christine Torres…
Category: 6. Health
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Human assembloids recapitulate periportal liver tissue in vitro
Human specimens
All human liver tissues used in this study were obtained after informed consent was obtained from patients undergoing operations at either the Department of Visceral, Thoracic and Vascular Surgery (VTG), University Hospital Carl…
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Astrocyte CCN1 stabilizes neural circuits in the adult brain
Animals
All animal experiments were approved by the Salk Institute Institutional Animal Care and Use Committee (IACUC). Rats and mice were typically housed with a standard 12 h:12 h light:dark cycle in the Salk Institute animal facilities,…
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Lesion-remote astrocytes govern microglia-mediated white matter repair
Mice
Young adult male and female mice were used between 2 and 4 months of age at the time of experimental procedures. C57BL/6 J mice (JAX: 000664) were used for experiments requiring a wild-type background. For RNA-seq of astrocyte-specific…
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Transient hepatic reconstitution of trophic factors enhances aged immunity
Ethical statement
All experiments were performed in compliance with all relevant ethical regulations as approved by the Institutional Biosafety Committee (IBC) of the Broad Institute (protocol #IBC-2017-00146). All animal experiments were approved…
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Gene-specific selective sweeps are pervasive across human gut microbiomes
Garud, N. R., Good, B. H., Hallatschek, O. & Pollard, K. S. Evolutionary dynamics of bacteria in the gut microbiome within and across hosts. PLoS Biol. 17, e3000102 (2019).
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Confused by the doctor’s questionnaire? U of A study suggests it’s common
Imagine sitting down for an appointment with a therapist – or any care provider. Perhaps it’s the first time you’ve seen this provider, or the first time in a while. You’ll likely need to fill out a form with a set of questions to ensure they…
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GLP-1 Agonists May Favorably Influence Metabolic Risk and Breast Cancer Outcomes
In this Q&A with Pharmacy Times, Joanne Mortimer, MD, FACP, FASCO, discusses emerging evidence on the safety and potential benefits of GLP-1 receptor agonists (RAs) in women with breast cancer. Mortimer explains that available data show no…
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Study finds 10% of over-70s in UK could have Alzheimer’s-like changes in brain | Alzheimer’s
One in 10 people in the UK aged 70 and older could have Alzheimer’s-like changes in their brain, according to the clearest, real-world picture of how common the disease’s brain changes are in ordinary, older people.
The detection of the…
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New study suggests a way to rejuvenate the immune system | MIT News
As people age, their immune system function declines. T cell populations become smaller and can’t react to pathogens as quickly, making people more susceptible to a variety of infections.
To try to overcome that decline,…
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