Category: 3. Business

  • Turning precision medicine into reality with statistics and data-driven decision making across pharmaceutical development

    Statistics and decision making are essential for enabling the broader success of precision medicine. We have identified the following strategies and factors as particularly impactful:

    Apply enrichment strategies consistently, starting in early phases

    Enrichment designs, which focus on recruiting patients most likely to benefit from the therapy, can improve trial efficiency and increase the likelihood of success. For example, targeting high-biomarker expressors in early-phase studies can de-risk later phases. A common challenge is that in early phases, there is limited knowledge on optimal biomarker cut-offs. This can be overcome with trial designs that adapt the biomarker cut-off and hence the degree of enrichment during the trial conduct9.

    Invest in robust biomarker subgroup identification and cut-off determination

    Identifying biomarker-based subgroups and determining biomarker cut-offs are critical. We acknowledge that this is a challenging task, especially when patient numbers are low. We still recommend starting early by identifying potentially predictive biomarkers (see e.g.10.) and optimizing cut-offs once more information is available. Bayesian methods and adaptive trial designs can help optimize cut-offs and guide decision-making.

    Use more adaptive trial designs

    Adaptive designs, in early-phase as well as in late-phase trials, allow for mid-trial modifications based on data accumulated, enabling more flexible and efficient exploration of biomarker-defined subgroups. This is particularly relevant if the subgroup is identified in a data-driven way during the trial, potentially using machine learning or other advanced methods. Solutions to seamlessly include data-driven subgroup identification into the trial design exist11 and we need to adopt them systematically. Conducting a systematic search of patient subgroups that is embedded in the clinical trial design will empower key decision-makers within an organization to choose between pursuing a precision medicine development approach or an all-comer development strategy.

    Integrate biomarker strategy into program strategy

    We have lost count of how often we have heard the statement that biomarker analyses are solely exploratory and hypothesis-generating. Without a clear goal on how the biomarkers impact the overall strategy, precision medicine is likely to fail. Biomarker statisticians should be involved from the outset to ensure that biomarker strategies are seamlessly integrated into the overall development plan. This includes providing risk assessments of complete program strategies for the entire program to evaluate trade-offs and risks. We recommend assessing different strategies for enrichment designs, subgroup identification and adaptive designs. Tools like probability of success12 and extensive simulations add substantial value in this context.

    Integrate scientific and commercial considerations

    Organizations should integrate precision medicine approaches from the earliest stages of drug development, combining both scientific and commercial considerations. This includes identifying disease endotypes through molecular characterization to enable precise patient stratification and inform adequately powered sub-population studies. As emphasized by Jenkins et al.13, biomarker studies require prospective planning with meaningful effect size specifications, even in exploratory phases, while gathering prior knowledge on variability sources and maintaining high data quality standards. Following established statistical frameworks, teams should ensure robust methodologies support their precision medicine strategies throughout the development continuum, enabling more targeted therapy development while optimizing resource allocation and enhancing clinical and commercial success probability.

    Leverage large datasets using AI/ML

    While exploratory biomarker discovery was rarely presented in the reviewed NDAs, large datasets (e.g., OMICS) collected in phase III/IV or sourced from external databases can be used for back-translation and identifying new biomarkers for future programs. Given the complexity and dimensionality of such data sets and the underlying disease biology, best practices and standardized application of Artificial Intelligence / Machine Learning (AI/ML) approaches should be employed to derive robust and actionable insights (see, e.g.14,15).

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  • Everus Construction Group (ECG) Valuation Check After Earnings Beat Backlog Record And Analyst Upgrades

    Everus Construction Group (ECG) Valuation Check After Earnings Beat Backlog Record And Analyst Upgrades

    Track your investments for FREE with Simply Wall St, the portfolio command center trusted by over 7 million individual investors worldwide.

    Everus Construction Group (ECG) reported earnings and revenue above forecasts, along with a record backlog that highlights strong booked work and has drawn investor attention to demand in data center, transmission, and distribution projects.

    See our latest analysis for Everus Construction Group.

    The latest moves in Everus Construction Group’s share price tell a story of building momentum, with a 7.6% 7 day share price return and a 38.9% year to date share price return sitting alongside a very large 1 year total shareholder return of 250.8%. Investors are absorbing strong earnings, acquisitions, and sector wide interest in construction names, with the stock at a last close of $123.88.

    If the demand Everus is seeing in data centers and grid projects has caught your attention, it may be worth scanning for other infrastructure beneficiaries through our AI infrastructure stocks screener, starting with 36 AI infrastructure stocks.

    With the shares already up 38.9% year to date and trading near a US$129.40 analyst target, the key question now is simple: are you looking at an undervalued compounder in infrastructure or a stock where markets are already pricing in future growth?

    Everus Construction Group’s most followed narrative points to a fair value of $105.67, below the last close of $123.88. This frames the current debate around expectations already embedded in the price.

    Escalating power infrastructure needs tied to data centers, electric vehicles, industrial reshoring and undergrounding are supporting sustained T&D backlog growth and higher revenue visibility, reinforcing multi year revenue expansion.

    Read the complete narrative.

    Want to see what growth path justifies paying above the implied fair value? The narrative leans heavily on steady expansion, firm margins and a future earnings base that needs to support a premium earnings multiple. Curious which assumptions really carry the weight in that calculation and how sensitive the fair value is to even small changes in these inputs? The full narrative lays that out in detail.

    Result: Fair Value of $105.67 (OVERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, this upbeat story can crack if data center projects slow or acquisitions fail to deliver expected synergies, which could challenge the current premium pricing.

    Find out about the key risks to this Everus Construction Group narrative.

    With sentiment clearly optimistic so far, this is the moment to check the numbers yourself, move quickly if you wish, and weigh up 3 key rewards

    If Everus has sharpened your focus on quality, do not stop here. Use the Simply Wall Street Screener to spot other opportunities that might suit your portfolio.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include ECG.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • Rail service disruptions and changes over Easter weekend – BBC

    Rail service disruptions and changes over Easter weekend – BBC

    1. Rail service disruptions and changes over Easter weekend  BBC
    2. Major Euston rail disruption across Easter weekend  BBC
    3. Travel warning issued with NO trains running to London Euston from Manchester for five days  Manchester Evening News
    4. Travel expert Simon Calder issues Easter travel disruption warning for anyone leaving London  Trending Now Infrastructure
    5. Easter Bank Holiday: EMR services may be busier than normal due to engineering works  West Bridgford Wire

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  • Impact of sugary drink taxes on beverage calories purchased in a national fast food restaurant chain: A quasi-experimental study | PLOS Medicine – PLOS

    1. Impact of sugary drink taxes on beverage calories purchased in a national fast food restaurant chain: A quasi-experimental study | PLOS Medicine  PLOS
    2. Sugary-Drink Taxes May Not Cut Fast-Food Beverage Calories  Medscape
    3. Sugary drink taxes are not effective in fast-food settings, drive-through analysis suggests  Medical Xpress

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  • Pillar Two Compliance in Hong Kong

    Pillar Two Compliance in Hong Kong

    Pillar Two Compliance in Hong Kong requires constituent entities of in-scope MNE groups to meet specific filing obligations, deadlines, and mandatory e-filing requirements under the GloBE rules and Hong Kong minimum top-up tax (HKMTT). With the regime now operational, this guide covers the top-up tax return and notification procedures, penalties for non-compliance, mandatory e-filing through the IRD’s Pillar Two Portal, and key practical considerations for MNEs preparing for their first filing cycle.


    Hong Kong began implementing the OECD’s Pillar Two global minimum tax rules for fiscal years starting on or after January 1, 2025. The rules, which generally apply to the Hong Kong-based constituent entities of multinational enterprise (MNE) groups with consolidated annual revenue of at least €750 million in two of the last four fiscal years, impose new reporting and top-up tax obligations under the GloBE rules and the Hong Kong minimum top-up tax (HKMTT). 

    With the regime now in force, in-scope MNEs should begin preparing early asHong Kong requires both an annual top-up tax notification and a top-up tax return, with deadlines determined by the group’s reporting fiscal year-end. On January 19, 2026, the Inland Revenue Department (IRD) launched the first phase of the Pillar Two Portal, requiring electronic submission of required top-up tax returns and notifications and marking the start of Hong Kong’s mandatory e-filing framework for Pillar Two compliance. 

    This is the second in our two-part series on Hong Kong’s implementation of the Pillar Two global minimum tax. To see the requirements for companies in Hong Kong under the GloBE rules, see Part I: A Guide to Global Minimum Tax in Hong Kong – Understanding the Rules for MNEs.

    Explore vital economic, geographic, and regulatory insights for business investors, managers, or expats to navigate Hong Kong’s business landscape. Our Online Business Guides offer explainer articles, news, useful tools, and videos from on-the-ground advisors who contribute to the Doing Business in Hong Kong knowledge.
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    Compliance procedures for in-scope MNEs and constituent entities in Hong Kong 

    Filing top-up tax returns 

    No later than 15 months after the last date of the reporting fiscal year, Hong Kong-based constituent entities of in-scope MNEs are required to submit a single top-up tax return for the purposes of the GloBE rules and HKMTT. However, the filing deadline for the first transition year has been extended to 18 months from the end of the reporting year. 

    For the first transition year of any constituent entities of an MNE group, the filing deadline has been extended to 18 months after the last day of the reporting fiscal year. In practice, groups should map their reporting fiscal year-end to the 15month (or 18month transition year) deadline and align local Hong Kong filings with the group’s overall GloBE reporting timetable.

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    The top-up tax return includes the information required in the standardized GloBE Information Return (GIR).   

    Hong Kong constituent entities can be relieved from the obligation to file the GIR information if the required information has already been filed in another jurisdiction that will be able to exchange GIR information with Hong Kong under a qualifying competent authority agreement.  

    Moreover, if an in-scope MNE has more than one constituent entity in Hong Kong, the entities can designate one entity to file the top-up tax return to the IRD. This entity must be appointed annually, and allows all other Hong Kong constituent entities of the group to be relieved of their filing obligation. 

    An assessor may require a constituent entity to provide information on whether the information provided in the top-up tax return is accurate and complete. Failure to comply may trigger penalties under the Inland Revenue Ordinance. 

    Filing of top-up tax notification 

    In addition to the top-up tax return, each Hong Kong constituent entity of an in-scope MNE group is required to file an annual top-up tax notification in a prescribed form and manner within six months after the last day of the reporting fiscal year. The notification must detail its obligations for filing a top-up tax return and is intended to inform the IRD of that the MNE is in scope of the GloBE rules and HKMTT and that the constituent entities is within the jurisdiction of Hong Kong for the purpose of the top-up tax filing obligations.  

    As with the top-up tax return, where there are multiple constituent entities of an in-scope MNE, they can appoint one entity to handle the filing procedures. 

    The notification must include (but is not limited to) the following information: 

    • The name, address, and business registration number of each of the MNE’s Hong Kong constituent entities;
    • If the MNE’s ultimate parent company is located in a jurisdiction other than Hong Kong, the jurisdiction the in-scope MNE’s ultimate parent company is located and its name, address, and business registration number;
    • Whether the GloBE filing is intended to be effected in Hong Kong for the fiscal year, and if so, the name, address, and business registration number of the entity designated to handle the filing in Hong Kong; and
    • Whether the GloBE filing is intended to be effected outside of Hong Kong for the fiscal year, and if so, the jurisdiction in which the GloBE information return will be filed, and the name, address, and business registration number of the entity designated to handle the filing in that jurisdiction. 

    Penalties for non-compliance 

    A constituent entity that fails to file the top-up tax return or top-up tax notification is liable for a fine at level 3 under the Criminal Procedure Ordinance (up to HK$10,000/US$1,279) and a further fine that is three times the amount of undercharged top-up tax.

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    Meanwhile, a constituent entity that fails to comply with an assessor’s request to provide additional information on a top-up tax return may be liable to a level 3 fine. 

    If a constituent entity files, or knowingly allows to be filed on its behalf, a top-up tax return or notification that is misleading, false, or inaccurate, or provides misleading, false, or inaccurate information regarding an MNE’s top-up tax liability, may be liable for a level 3 fine and a further fine of three times the amount of undercharged top-up tax. 

    Mandatory electronic filing 

    The top-up tax returns and notifications must be filed electronically through the Pillar Two Portal by the designated constituent entity. This Pillar Two Portal is an extension of the Business Tax Portal and is accessed through the latter platform. 

    These mandatory electronic filing procedures are being implemented in two phases: 

    • Phase one: Launched on January 19, 2026, for designated entities to file the top-up tax notification.
    • Phase two: To be launched in the fourth quarter of 2026 for designated entities to file the top-up tax return, as well as for the entities to view and download notices of top-up tax assessments. 

    Entities tasked with filing these documents must register their designated business accounts under the Business Tax Portal to access the Pillar Two Portal directly. The individuals tasked with signing and submitting top-up tax notifications and returns on behalf of the entity must use their e-cert (Organisational) with AEOI Functions for the purposes of authentication. 

    Mandatory e-filing of profits tax return 

    In addition to the top-up tax return, certain applicable constituent entities of in-scope MNEs are also required to file their profits tax return for a year of assessment (YA) beginning on or after April 1, 2025.  

    The mandatory e-filing applies to: 

    • Profits Tax Return – Corporations (BIR 51); and
    • Profits Tax Return – Persons Other Than Corporations (BIR 52). 

    Constituent entities that are subject to the mandatory e-filing of profits tax returns are those that meet both of the following criteria: 

    1. The entity is a Part 4AA entity of an MNE (see Part I) for a fiscal year beginning on or after January 1, 2025, corresponding to the applicable YA.
    2. The MNE to which the Part 4AA entity is an in-scope MNE for a fiscal year beginning on or after January 1, 2025, corresponding to the applicable YA, or preceding the fiscal year corresponding to the applicable YA. 

    A “fiscal year corresponding to the applicable YA” refers to the fiscal year of the MNE group within which the basis period of the YA of the entity ends (the YA beginning on or after April 1, 2025). 

    The e-filing system adopts a “once-in, always-in” mechanism, meaning that if an entity is required to e-file a profits tax return under phase one for a given year of assessment (YA), it will be required to e-file this tax return for every subsequent YA. This applies regardless of whether the entity meets the two above conditions for any subsequent YA. It will generally also apply to entities subject to the phase one filing requirements that subsequently leave an in-scope MNE, as well as to those entities whose MNEs subsequently become out of scope. 

    Exemptions

    Entities may be subject to the phase one mandatory e-filing requirements, and may be permitted to file the profits tax return in paper form in the following circumstances: 

    1. It is being wound up or amalgamated pursuant to the Companies (Winding Up and Miscellaneous Provisions) Ordinance or Companies Ordinance;
    2. It has no record in the Business Register;
    3. It has notified the Companies Registry or Business Registration Office of its date of cessation;
    4. The accounting period of its financial statement that is to be submitted with the profits tax return exceeds 12 months;
    5. The profits tax return for the YA 2025/26 is issued on or before March 31, 2026; or
    6. For the purposes of refiling a profits tax return previously e-filed but found to be invalid. 

    Any supplementary forms must still be filed electronically. 

    Considerations for MNEs 

    With Hong Kong’s Pillar Two compliance framework now operational, in-scope MNEs should ensure that internal processes, responsible entities, and electronic filing access are fully in place. This includes confirming which Hong Kong constituent entity will be designated for filings, aligning reporting timelines with group-level compliance obligations, and preparing for mandatory e-filing through the Pillar Two Portal and the Business Tax Portal.

    Related Reading

    Jennifer Lu, Partner at Dezan Shira & Associates, emphasizes that the primary Pillar Two risk for MNEs in Hong Kong lies less in technical interpretation and more in execution. Common challenges arise where group‑level GloBE calculations are not fully aligned with local Hong Kong filing requirements, where internal ownership of Pillar Two compliance is unclear across tax and finance teams, or where portal registration and access arrangements are addressed too late in the process. 

    From an advisory perspective, we recommend that inscope MNEs approach Pillar Two compliance as an ongoing governance and operational exercise, rather than a oneoff filing obligation. As a practical next step, many groups benefit from conducting an early readiness review, covering scope confirmation, designation of Hong Kong filing entities, data availability, internal review and signoff processes, and access to the Pillar Two Portal. Taking these steps well ahead of the first notification and filing deadlines can materially reduce execution risk, avoid lastminute remediation, and provide management with greater certainty over compliance outcomes.  

    Jennifer Lu
    DSA

    quote

    Tax planning and compliance in Hong Kong require careful navigation of evolving local and international tax rules. Our experienced advisors support businesses with corporate tax, indirect tax, individual tax, international tax, and transfer pricing, helping them remain compliant while optimizing their tax position in Hong Kong and the wider Asia?Pacific region.

    Partner

    About Us

    China Briefing is one of five regional Asia Briefing publications. It is supported by Dezan Shira & Associates, a pan-Asia, multi-disciplinary professional services firm that assists foreign investors throughout Asia, including through offices in Beijing, Tianjin, Dalian, Qingdao, Shanghai, Hangzhou, Ningbo, Suzhou, Guangzhou, Haikou, Zhongshan, Shenzhen, and Hong Kong in China. Dezan Shira & Associates also maintains offices or has alliance partners assisting foreign investors in Vietnam, Indonesia, Singapore, India, Malaysia, Mongolia, Dubai (UAE), Japan, South Korea, Nepal, The Philippines, Sri Lanka, Thailand, Italy, Germany, Bangladesh, Australia, United States, and United Kingdom and Ireland.

    For a complimentary subscription to China Briefing’s content products, please click here. For support with establishing a business in China or for assistance in analyzing and entering markets, please contact the firm at china@dezshira.com or visit our website at www.dezshira.com.

     

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  • Asian Shares Gain as Volatile Week Draws to an End: Markets Wrap

    Asian Shares Gain as Volatile Week Draws to an End: Markets Wrap

    (Bloomberg) — Asian stocks advanced at the end of another volatile week fueled by the Middle-East conflict. Attention also started to turn Friday’s release of key US payrolls data.

    MSCI’s benchmark Asia Pacific Index gained as much as 1% after the S&P 500 Index closed 0.1% higher, reversing an earlier loss of 1.5%. Sentiment toward equities improved after oil prices eased off their highs following a report that Iran is drafting a protocol with Oman to monitor traffic through the Strait of Hormuz, having effectively shut it down since the start of the war.

    “The improvement in U.S. risk appetite has spilled over” into regional equities, said Hitoshi Asaoka, chief strategist at Asset Management One Co. in Tokyo. “While oil prices may not fully return to previous levels, if they do partially normalize, there is considerable room for a rebound from a liquidity perspective.”

    A number of Asian markets were shut for holidays Friday including Australia, New Zealand, Hong Kong, Singapore, the Philippines and Indonesia. US stock markets will also be closed for a holiday, though the government is still scheduled to publish a slate of economic data, including March nonfarm payrolls.

    South Korea led regional equity gains with the benchmark Kospi jumping as much as 3.5%, while Japan’s Nikkei 225 Stock Average rose 1.1%. China’s CSI 300 Index reversed an earlier advance to drop 0.4%.

    Treasury futures were little changed in Asia with the cash market shut until US hours for a half day of trading.

    US stocks had started off Thursday deep in the red after a speech from Trump late Wednesday did little to reassure investors that the war in the Middle East was nearing a swift resolution, though he has previously set a two-to-three-week timeline for ending the conflict. On Thursday, the president issued fresh threats on Iranian infrastructure in a bid to pressure Tehran in negotiations.

    “With U.S. payrolls coming up and a holiday ahead, markets are wary of what could happen over the weekend — especially the first weekend after,” Trump’s speech said Rina Oshimo, a senior strategist at Okasan Securities Co. in Tokyo. “If attacks escalate or retaliations occur, oil prices could remain elevated for longer.”

    Oil rallied above $110 a barrel Thursday after Trump vowed an escalation in the war in Iran over the coming weeks. West Texas Intermediate surged 11%, while the global Brent benchmark settled near $109. Europe’s diesel futures benchmark climbed above $200 a barrel for the first time since 2022.

    War Pattern

    The higher close for the S&P 500 on Thursday ran counter to a pattern of late-week selloffs that have hit the market ever since the war began, as nervous investors unwind positions that could be upended if weekend developments threaten to worsen the hit to the global economy.

    “While assets gyrate on every new headline, until a clear agreement is achieved with a palatable plan for reopening the Strait, there’ll be downward pressure on economic growth and upward pressure on headline inflation,” said Max Gokhman, deputy CIO, Franklin Templeton Investment Solutions. “That spells indigestion for both equity and bond investors.”

    Tesla Inc. shares fell after the company posted one of its worst sales quarters in years, missing Wall Street’s expectations, as it struggles to turn around its core business and navigate an increasingly challenged electric-vehicle market.

    US labor-market data on Thursday gave mixed signals. A report from Challenger, Gray & Christmas Inc. showed a 25% increase in job-cut announcements in March from the previous month. Meanwhile, initial jobless claims unexpectedly fell in the week through March 28.

    Corporate News:

    A group of private credit firms led by Blackstone Inc. has refused to extend another lifeline to software company Medallia, amping up pressure on owner Thoma Bravo to inject more equity into the troubled business or hand over the keys via a debt restructuring. Stellantis NV is discussing options for building electric vehicles in Canada with its Chinese partner, Zhejiang Leapmotor Technology Co., according to people familiar with the matter. Alibaba Group Holding Ltd. has released its third proprietary AI model in as many days, reinforcing the company’s intent to focus on profiting off its flagship artificial intelligence services. Some of the main moves in markets:

    Stocks

    S&P 500 futures fell 0.2% as of 11:31 a.m. Tokyo time Hang Seng futures rose 0.6% Nikkei 225 futures (OSE) rose 1.2% S&P/ASX 200 futures were little changed Japan’s Topix rose 0.6% The Shanghai Composite fell 0.5% Currencies

    The Bloomberg Dollar Spot Index rose 0.3% The euro was little changed at $1.1533 The Japanese yen was little changed at 159.68 per dollar The offshore yuan was little changed at 6.8850 per dollar Cryptocurrencies

    Bitcoin fell 0.8% to $66,392.95 Ether fell 1.1% to $2,044.91 This story was produced with the assistance of Bloomberg Automation.

    ©2026 Bloomberg L.P.

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  • Stellantis recalls 44,000 UK vehicles over fault that could cause fires | Stellantis

    Stellantis recalls 44,000 UK vehicles over fault that could cause fires | Stellantis

    The European carmaker Stellantis has issued a recall for 44,000 UK vehicles after discovering a fault that could result in its cars catching fire.

    The fault has been found in certain models across its Peugeot, Citroën, DS Automobiles, Vauxhall, Lancia, Alfa Romeo, Jeep and Fiat brands, produced between 2023 and 2026. Key vehicles affected by the recall include the Citroën C3, Peugeot 208 and Vauxhall Mokka.

    The manufacturer said the issue related to a lack of clearance between the gas filter pipe and a component of the belt starter generator, which could cause water to leak into the engine bay during wet driving conditions. That created a “potential risk of fire” in the engine, in the worst-case scenario.

    In a statement, Stellantis said it was voluntarily recalling an estimated 44,000 vehicles in the UK in response, and would immediately contact affected car owners asking them to get in touch with their dealer to schedule an appointment, adding that the service would be offered free of charge.

    It is the latest setback for the vehiclemaker, which in February was forced to take a €22bn (£19.1bn) charge and sell a stake in its battery joint venture after admitting that it “overestimated” the pace of the shift to electric vehicles. The move means the company has been forced to cancel its previously planned Ram 1500 BEV, an electric truck it had claimed was “set to push boundaries”.

    While sales of electric vehicles in Europe have soared, demand in the US has collapsed after the Trump administration withdrew a $7,500 (£5,527) consumer tax credit, and is looking to remove regulations aimed at curbing car emissions.

    Stellantis is planning to sell its 49% stake in its battery joint venture in Canada with NextStar Energy to South Korea’s LG Energy Solution, and said it would not be paying a dividend to shareholders in 2026. Analysts expect that the company will still have to consider factory closures and a reduction in output.

    News of Stellantis’s recall came as rival Jaguar Land Rover (JLR) revealed a recovery in sales over the past quarter, as it restarted production after last autumn’s damaging cyber-attack. The incident forced the company to halt production across its UK factories for five weeks from last September and weighed on its full-year sales.

    JLR, the UK’s largest car manufacturer, which is owned by India’s Tata, said it sold 95,300 vehicles to dealers in the three months to 31 March, a 61.1% jump on the previous quarter.

    However, quarterly sales to dealerships were still down 14.5% during the same period a year earlier, a drop that it blamed on the cyber incident, US tariffs, market challenges in China and the planned wind-down of some legacy Jaguar models.

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  • Alleged maple syrup scam in Quebec uncovered by Canadian broadcaster | Quebec

    Alleged maple syrup scam in Quebec uncovered by Canadian broadcaster | Quebec

    An investigation by Canada’s national broadcaster has found that a major Quebec producer has been diluting its maple syrup with cane sugar and selling the fraudulent product to grocery chains.

    In a sting operation that involved false identities and covert recordings, journalists from Radio-Canada’s Enquête programme found that a low-cost syrup sold in major grocery store chains was heavily diluted.

    Samples of the brand, which is sold in hundreds of locations across Quebec, were sent to the province’s research and testing facility, Le Centre ACER.

    “This is the first time I’ve seen falsification of this kind. You can see that it’s outright cane sugar that’s been added to the cans,” Luc Lagacé, a microbiologist and the director of research at ACER, told Enquête. “This is not an accident. It’s deliberate.”

    Maple syrup is a dominant industry in Quebec, where decades of technological innovation and investment helped farmers harvest 239m pounds of it last year. The Francophone province is responsible for nearly all of Canada’s production and nearly three-quarters of global production. A barrel of syrup is worth nearly C$1,000.

    The industry is worth nearly C$1bn annually and the immense value of the market has lured criminal elements to Quebec’s global strategic reserve of syrup.

    In 2011, thieves slowly siphoned off maple syrup worth nearly C$18m from the stockpile, a heist that led to 40 arrests and jail sentences for five men.

    The investigation into the fraudulent syrup began when a reporter at CBC’s Radio Canada discovered an odd taste to the syrup he had bought. The can was labelled “pure maple syrup” and linked to a producer south-west of Montreal, Steve Bourdeau.

    Enquête had two people pose as buyers for a grocery store to reach out to Bourdeau.

    The journalists taped telephone conversations and later used a hidden camera to capture footage of Bourdeau. He told the reporters he knew it was illegal to cut maple syrup labelled as pure with other sugars – and said that he didn’t do that.

    Bourdeau’s syrup is sold by major grocery chains, including IGA and Metro.

    “I’m the best when it comes to prices. The others can’t even come close,” he said, adding his maple syrup cost less than C$5 a can. “There’s a lot of jealousy going on. Because I have the market. And it’s not entirely legal. And I got away with it anyway.”

    When Bourdeau was confronted with the findings from the lab tests, he initially denied the allegations before suggesting a supplier from outside the province was to blame.

    He told reporters he was launching his own investigation to try to determine how cane sugar had been mixed in with his product and would implement his own inspection system.

    The head of Quebec’s sprawling stockpile of syrup told CBC that using suppliers from outside the province was not illegal – but falsely labelling such syrup as having Quebecois origins was.

    Geneviève Clermont, head of ACER’s inspection division, said 90% of syrup from Quebec sold in bulk was tested, but she said that products canned and sold by producers themselves were not inspected regularly.

    Many of the popular maple-flavoured syrups sold in the US are made of corn syrup (or high-fructose corn syrup) with added flavourings and caramel to give the amber-like appearance of genuine maple syrup.

    Producing maple syrup, which can only occur during a narrow window of time in the spring, requires immense volumes of sap, which is then boiled down into the final product.

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  • Major London Euston rail disruption due across Easter weekend – bbc.com

    Major London Euston rail disruption due across Easter weekend – bbc.com

    1. Major London Euston rail disruption due across Easter weekend  bbc.com
    2. ‘Most of our trains are running normally this Easter’, rail operator tells passengers  Northern Rail
    3. Travel warning issued with NO trains running to London Euston from Manchester for five days  Manchester Evening News
    4. Travel expert Simon Calder issues Easter travel disruption warning for anyone leaving London  Trending Now Infrastructure
    5. Easter chaos as UK’s busiest train line to shut in HOURS for £400m upgrade  The Irish Sun

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  • CU Boulder and Techstars Announce Partnership to Accelerate Colorado’s Entrepreneurial Ecosystem

    CU Boulder and Techstars Announce Partnership to Accelerate Colorado’s Entrepreneurial Ecosystem

    The University of Colorado Boulder and Techstars, the global startup accelerator and investor, have announced a strategic partnership to expand opportunities for founders and strengthen Colorado’s innovation economy.

    The collaboration connects CU Boulder’s entrepreneurship programs and startup pipeline with Techstars’ network of mentors, investors and partners — creating new pathways for innovators to build and scale companies that drive real-world impact.

    “This partnership reflects CU Boulder’s commitment to empowering people across our campus to turn ideas into impact,” said Massimo Ruzzene, senior vice chancellor for research and innovation and dean of the institutes. “Our students, faculty and researchers are developing technologies, launching companies and exploring solutions to real challenges. Working with Techstars connects that talent with a global community of entrepreneurs and investors who can help move those ideas from campus into the world.”

    From Discovery to Startup

    CU Boulder has emerged as one of the most vibrant entrepreneurial ecosystems on a university campus in the United States. Through research, entrepreneurial education and the campus-wide Innovation & Entrepreneurship Initiative, the university supports students and faculty pursuing new ventures based on breakthrough discoveries.

    Venture Partners at CU Boulder — the university’s commercialization arm — has played a central role in that momentum and in initiating the new partnership. Through Venture Partners, more than 220 companies based on CU Boulder technologies have launched and collectively exited for over $11 billion. The campus was ranked first in the nation for the number of such startups launched in 2024, the second most ever launched by a single university campus in one year.

    The partnership with Techstars will connect CU Boulder’s innovation ecosystem with one of the world’s premier startup accelerators and investors.

    Established in Boulder in 2006 by David Cohen, Brad Feld, David Brown, and Jared Polis, Techstars helped shape the city’s startup culture. What began as a single accelerator program has grown into a global platform supporting founders across industries and geographies.

    “Techstars has operated continuously in Colorado for two decades. The re-launch of our Techstars Boulder accelerator here reflects our renewed commitment to Colorado and reinforces Boulder’s role as an important hub in our system,” said David Cohen, chief executive officer of Techstars and co-founder of the company. “CU Boulder is a powerful source of new ideas and new companies. By building a deeper relationship with the university, we can help more founders turn breakthroughs into companies that scale.”

    Today, Techstars has invested in thousands of startups worldwide, whose combined market value exceeds $220 billion.

    CU Boulder and Techstars count dozens of unicorns between them, including DigitalOcean, SendGrid, Salesloft, and Veho (Techstars), Infleqtion, Ball Aerospace & Technologies, Solid Power, and SomaLogic (CU Boulder).

    Expanding Pathways for Founders

    CU Boulder’s students and faculty will engage with Techstars staff, mentors and alumni through university entrepreneurship programs such as the New Venture Challenge and Embark Deep Tech Startup Creator. The collaboration will also create opportunities for Techstars founders to work with CU Boulder researchers and students while accessing specialized facilities and technical expertise.

    For startups emerging from the university, the partnership opens a direct pathway to Techstars’ accelerator programs and investor network.

    “This collaboration brings together two communities deeply committed to building great companies,” said Shay Har-Noy, managing director of Techstars Boulder. “CU Boulder consistently produces exceptional research, founders and high-potential companies. By working closely, we can help even more of these teams scale into enduring, world-class businesses.”

    “Techstars Boulder just opened applications for its first new cohort, kicking off in person this September,” said Har-Noy, “We’re passionate about backing the strongest founders and companies from CU Boulder, across Colorado and from around the country.”

    Strengthening Colorado’s Innovation Economy

    The partnership strengthens the connection between CU Boulder’s research and academic mission and the global entrepreneurial ecosystem while expanding opportunities for founders emerging from the university.

    “Boulder has long been a catalyst where research, entrepreneurship and community come together to improve people’s lives,” said Bryn Rees, senior associate vice chancellor for innovation and partnerships at CU Boulder. “This partnership with Techstars builds on that foundation. Together, we can help more great ideas become companies and more founders bring transformative ideas to the world.”

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