Qaasid News

Download Our App

Category: 3. Business

  • SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression

    SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression

  • Pape K, Tamouza R, Leboyer M, Zipp F. Immunoneuropsychiatry – novel perspectives on brain disorders. Nat Rev Neurol. 2019;15:317–28.

    Article 
    PubMed 

    Google Scholar 

  • Welcome MO, Mastorakis NE. Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways. Pharmacol Res. 2020;157:104769.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol. 2016;16:22–34.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Torres-Berrio A, Estill M, Patel V, Ramakrishnan A, Kronman H, Minier-Toribio A, et al. Mono-methylation of lysine 27 at histone 3 confers lifelong susceptibility to stress. Neuron. 2024;112:2973–89.e10.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Padeken J, Methot SP, Gasser SM. Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance. Nat Rev Mol Cell Biol. 2022;23:623–40.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wang DY, Kosowan J, Samsom J, Leung L, Zhang KL, Li YX, et al. Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice. Acta Pharmacol Sin. 2018;39:866–74.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tan SL, Nishi M, Ohtsuka T, Matsui T, Takemoto K, Kamio-Miura A, et al. Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development. Development. 2012;139:3806–16.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zhu Y, Sun D, Jakovcevski M, Jiang Y. Epigenetic mechanism of SETDB1 in brain: implications for neuropsychiatric disorders. Transl Psychiatry. 2020;10:115.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jiang Y, Jakovcevski M, Bharadwaj R, Connor C, Schroeder FA, Lin CL, et al. Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. J Neurosci. 2010;30:7152–67.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Li J, Zheng S, Dong Y, Xu H, Zhu Y, Weng J, et al. Histone Methyltransferase SETDB1 Regulates the Development of Cortical Htr3a-Positive Interneurons and Mood Behaviors. Biol Psychiatry. 2023;93:279–90.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, et al. KAP1 controls endogenous retroviruses in embryonic stem cells. Nature. 2010;463:237–40.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, et al. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. Nature. 2021;595:309–14.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Rolland A, Jouvin-Marche E, Viret C, Faure M, Perron H, Marche PN. The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses. J Immunol. 2006;176:7636–44.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chandrasekaran S, Espeso-Gil S, Loh YE, Javidfar B, Kassim B, Zhu Y, et al. Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions. Nat Commun. 2021;12:7243.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Barden N, Harvey M, Gagne B, Shink E, Tremblay M, Raymond C, et al. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:374–82.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lucae S, Salyakina D, Barden N, Harvey M, Gagne B, Labbe M, et al. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum Mol Genet. 2006;15:2438–45.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kristof Z, Gal Z, Torok D, Eszlari N, Sutori S, Erdelyi-Hamza B, et al. Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation. Sci Rep. 2023;13:7757.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Troubat R, Leman S, Pinchaud K, Surget A, Barone P, Roger S, et al. Brain immune cells characterization in UCMS exposed P2X7 knock-out mouse. Brain Behav Immun. 2021;94:159–74.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • von Muecke-Heim IA, Ries C, Urbina L, Deussing JM. P2X7R antagonists in chronic stress-based depression models: a review. Eur Arch Psychiatry Clin Neurosci. 2021;271:1343–58.

    Article 

    Google Scholar 

  • Sidoryk-Wegrzynowicz M, Struzynska L. Astroglial and microglial purinergic P2X7 receptor as a major contributor to neuroinflammation during the course of multiple sclerosis. Int J Mol Sci. 2021;22:8404.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • He Y, Taylor N, Fourgeaud L, Bhattacharya A. The role of microglial P2X7: modulation of cell death and cytokine release. J Neuroinflammation. 2017;14:135.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Miras-Portugal MT, Sebastian-Serrano A, de Diego Garcia L, Diaz-Hernandez M. Neuronal P2X7 receptor: involvement in neuronal physiology and pathology. J Neurosci. 2017;37:7063–72.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ohishi A, Keno Y, Marumiya A, Sudo Y, Uda Y, Matsuda K, et al. Expression level of P2X7 receptor is a determinant of ATP-induced death of mouse cultured neurons. Neuroscience. 2016;319:35–45.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sebastian-Serrano A, Engel T, de Diego-Garcia L, Olivos-Ore LA, Arribas-Blazquez M, Martinez-Frailes C, et al. Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation. Hum Mol Genet. 2016;25:4143–56.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Shin YH, Kim M, Kim N, Choi SK, Namkoong E, Choi SY, et al. Epigenetic alteration of the purinergic type 7 receptor in salivary epithelial cells. Biochem Biophys Res Commun. 2015;466:704–10.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, Concannon C, Olivos-Ore LA, Reschke CR, et al. microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. Sci Rep. 2015;5:17486.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Garcia-Huerta P, Diaz-Hernandez M, Delicado EG, Pimentel-Santillana M, Miras-Portugal MT, Gomez-Villafuertes R. The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system. J Biol Chem. 2012;287:44628–44.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S. The P2X7 Receptor in Infection and Inflammation. Immunity. 2017;47:15–31.

    Article 
    PubMed 

    Google Scholar 

  • Bennett MR. Synaptic P2X7 receptor regenerative-loop hypothesis for depression. Aust N Z J Psychiatry. 2007;41:563–71.

    Article 
    PubMed 

    Google Scholar 

  • Vitureira N, Rafael A, Abudara V. P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission. Purinergic Signal. 2024;20:223–36.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Munoz FM, Gao R, Tian Y, Henstenburg BA, Barrett JE, Hu H. Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice. Sci Rep. 2017;7:3539.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fellin T, Pozzan T, Carmignoto G. Purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes. J Biol Chem. 2006;281:4274–84.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, et al. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nat Genet. 2017;49:1239–50.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen L, Faas GC, Ferando I, Mody I. Novel insights into the behavioral analysis of mice subjected to the forced-swim test. Transl Psychiatry. 2015;5:e551.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Troubat R, Barone P, Leman S, Desmidt T, Cressant A, Atanasova B, et al. Neuroinflammation and depression: A review. Eur J Neurosci. 2021;53:151–71.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kato M, Takemoto K, Shinkai Y. A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing. Nat Commun. 2018;9:1683.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • He J, Babarinde IA, Sun L, Xu S, Chen R, Shi J, et al. Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE. Nat Commun. 2021;12:1456.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, et al. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023;186:287–304.e26.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Liu S, Heumuller SE, Hossinger A, Muller SA, Buravlova O, Lichtenthaler SF, et al. Reactivated endogenous retroviruses promote protein aggregate spreading. Nat Commun. 2023;14:5034.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Aalling N, et al. SOX9 Is an astrocyte-specific nuclear marker in the adult brain outside the neurogenic regions. J Neurosci. 2017;37:4493–507.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Li P, Wei J, Zhu Y. CellGO: a novel deep learning-based framework and webserver for cell-type-specific gene function interpretation. Brief Bioinform. 2023;25:bbad417.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Witt I, Straub N, Kaufer NF, Gross T. The CAGTCACA box in the fission yeast Schizosaccharomyces pombe functions like a TATA element and binds a novel factor. EMBO J. 1993;12:1201–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cho MJ, Lee DG, Lee JW, Hwang B, Yoon SJ, Lee SJ, et al. Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-kappaB inactivation. Cardiovasc Res. 2023;119:1265–78.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ge SX, Jung D, Yao R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics. 2020;36:2628–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Guo M, Zhu J, Hu Z, Wang Q, Songyang Z, Xiong Y. Histone mRNA polyadenylation-mediated inflammation underlies various virus infections and cancers. J Med Virol. 2023;95:e28826.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, et al. A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. Nat Cell Biol. 2019;21:731–42.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2:725–34.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Pastuzyn ED, Day CE, Kearns RB, Kyrke-Smith M, Taibi AV, McCormick J, et al. The neuronal gene arc encodes a repurposed retrotransposon Gag protein that mediates intercellular RNA transfer. Cell. 2018;172:275–88.e18.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Manghera M, Douville RN. Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors? Retrovirology. 2013;10:16.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kwon DN, Lee YK, Greenhalgh DG, Cho K. Lipopolysaccharide stress induces cell-type specific production of murine leukemia virus type-endogenous retroviral virions in primary lymphoid cells. J Gen Virol. 2011;92:292–300.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wu B, Peng L, Xie J, Zou L, Zhu Q, Jiang H, et al. The P2X(7) receptor in dorsal root ganglia is involved in HIV gp120-associated neuropathic pain. Brain Res Bull. 2017;135:25–32.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Yang R, Yu T, Kou X, Gao X, Chen C, Liu D, et al. Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter. Nat Commun. 2018;9:2143.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Parisi C, Napoli G, Amadio S, Spalloni A, Apolloni S, Longone P, et al. MicroRNA-125b regulates microglia activation and motor neuron death in ALS. Cell Death Differ. 2016;23:531–41.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Engel T, Brennan GP, Sanz-Rodriguez A, Alves M, Beamer E, Watters O, et al. A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22. Biochim Biophys Acta Mol Cell Res. 2017;1864:255–66.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Hashimoto-Hill S, Friesen L, Kim M, Kim CH. Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7. Mucosal Immunol. 2017;10:912–23.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Shoulders CC, Naoumova RP. USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome. Trends Mol Med. 2004;10:362–5.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Albalawi F, Lu W, Beckel JM, Lim JC, McCaughey SA, Mitchell CH. The P2X7 receptor primes IL-1beta and the NLRP3 inflammasome in astrocytes exposed to mechanical strain. Front Cell Neurosci. 2017;11:227.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Illes P. P2X7 receptors amplify CNS damage in neurodegenerative diseases. Int J Mol Sci. 2020;21:5996.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tao C, Zhang GW, Sun WJ, Huang JJ, Zhang LI, Tao HW. Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states. Nat Commun. 2024;15:8575.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, et al. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology. 2018;43:2154–60.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, et al. P2X(7)R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes. Brain Behav Immun. 2023;114:414–29.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen R, Ishak CA, De Carvalho DD. Endogenous retroelements and the viral mimicry response in cancer therapy and cellular homeostasis. Cancer Discov. 2021;11:2707–25.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zhou J, Geng Y, Su T, Wang Q, Ren Y, Zhao J, et al. NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury. Cell Rep. 2022;38:110557.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lima-Junior DS, Krishnamurthy SR, Bouladoux N, Collins N, Han SJ, Chen EY, et al. Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota. Cell. 2021;184:3794–811.e19.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Karlsson H, Bachmann S, Schroder J, McArthur J, Torrey EF, Yolken RH. Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Proc Natl Acad Sci USA. 2001;98:4634–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Balestrieri E, Arpino C, Matteucci C, Sorrentino R, Pica F, Alessandrelli R, et al. HERVs expression in autism spectrum disorders. PLoS One. 2012;7:e48831.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Giuliano CJ, Lin A, Girish V, Sheltzer JM. Generating single cell-derived knockout clones in mammalian cells with CRISPR/Cas9. Curr Protoc Mol Biol. 2019;128:e100.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kantzer CG, Boutin C, Herzig ID, Wittwer C, Reiss S, Tiveron MC, et al. Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes. Glia. 2017;65:990–1004.

    Article 
    PubMed 

    Google Scholar 

  • Zheng GX, Terry JM, Belgrader P, Ryvkin P, Bent ZW, Wilson R, et al. Massively parallel digital transcriptional profiling of single cells. Nat Commun. 2017;8:14049.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Caglayan E, Liu Y, Konopka G. Neuronal ambient RNA contamination causes misinterpreted and masked cell types in brain single-nuclei datasets. Neuron. 2022;110:4043–56.e5.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, et al. Integrated analysis of multimodal single-cell data. Cell. 2021;184:3573–87.e29.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15–21.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Jin Y, Tam OH, Paniagua E, Hammell M. TEtranscripts: a package for including transposable elements in differential expression analysis of RNA-seq datasets. Bioinformatics. 2015;31:3593–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

Continue Reading

  • Assessing GDS Holdings (GDS) After Its Strong Multi‑Year Share Price Recovery

    Assessing GDS Holdings (GDS) After Its Strong Multi‑Year Share Price Recovery

    Find your next quality investment with Simply Wall St’s easy and powerful screener, trusted by over 7 million individual investors worldwide.

    • If you are wondering whether GDS Holdings at around US$39.91 is still good value after a strong run, this breakdown is designed to help you size up what the current price might be implying.

    • The stock has seen a 1.2% decline over the last 7 days, a 4.7% gain over 30 days, is up 4.1% year to date, 85.8% over 1 year, 123.7% over 3 years, but is 49.0% lower over 5 years. This gives a mixed picture for anyone trying to judge risk and potential.

    • Recent headlines around GDS Holdings have focused on the company’s position in its market and how investors are reassessing the stock after such a strong 1 year and 3 year return profile. That context matters for valuation, because sentiment and expectations often shape how far investors are willing to stretch on price.

    • Despite those moves, GDS Holdings currently records a valuation score of 0 out of 6. The next sections will walk through the key valuation approaches commonly used on this stock and then finish with a more complete way to think about what the current price might mean.

    GDS Holdings scores just 0/6 on our valuation checks. See what other red flags we found in the full valuation breakdown.

    A Discounted Cash Flow, or DCF, model projects a company’s future cash flows and then discounts those cash flows back to today to estimate what the business might be worth right now.

    For GDS Holdings, the model used is a 2 Stage Free Cash Flow to Equity approach, based on cash flows in CN¥. The latest twelve month free cash flow is a loss of CN¥727.76 million. Analyst inputs and projections show free cash flow staying negative for several years, then shifting to positive, reaching CN¥467.10 million in 2030, with further projected growth beyond that based on extrapolations.

    When all those projected cash flows are discounted back to today, the DCF model produces an estimated intrinsic value of about CN¥0.59 per share. Compared with the current share price of about US$39.91, this model output characterizes the stock as very overvalued, with an intrinsic discount figure of 6,640.7%.

    Result: OVERVALUED

    Our Discounted Cash Flow (DCF) analysis suggests GDS Holdings may be overvalued by 6640.7%. Discover 59 high quality undervalued stocks or create your own screener to find better value opportunities.

    GDS Discounted Cash Flow as at Apr 2026

    Head to the Valuation section of our Company Report for more details on how we arrive at this Fair Value for GDS Holdings.

    For companies that are generating earnings, the P/E ratio is a straightforward way to see how much you are paying for each dollar of profit. Higher growth expectations and lower perceived risk usually support a higher P/E, while slower growth or higher risk tend to justify a lower, more conservative multiple.

    GDS Holdings currently trades on a P/E of 61.47x. That is above the broader IT industry average P/E of 20.08x and also above the peer group average of 50.81x. On the surface, that suggests investors are paying a higher price for the company’s earnings than for many industry peers.

    Simply Wall St’s Fair Ratio for GDS Holdings is 34.26x. This Fair Ratio is a proprietary estimate of what a more appropriate P/E might be, taking into account factors such as earnings growth, industry, profit margins, market cap and specific risks. Because it is tailored to the company, it can provide a more rounded reference point than a simple comparison with peers or the industry alone.

    Comparing the current P/E of 61.47x with the Fair Ratio of 34.26x points to the shares trading above that Fair Ratio benchmark.

    Result: OVERVALUED

    NasdaqGM:GDS P/E Ratio as at Apr 2026
    NasdaqGM:GDS P/E Ratio as at Apr 2026

    P/E ratios tell one story, but what if the real opportunity lies elsewhere? Start investing in legacies, not executives. Discover our 20 top founder-led companies.

    Earlier the article mentioned that there is an even better way to understand valuation, so here is Narratives, a simple framework where you set out your story for GDS Holdings, link it to a forecast for revenue, earnings and margins, and arrive at your own fair value that you can compare with the current price.

    On Simply Wall St’s Community page, Narratives are easy to use and widely shared, and they help you decide whether GDS Holdings looks attractive or stretched by showing the gap between your Fair Value and the latest market price. They also update that view automatically when new earnings, guidance or news is released.

    For GDS Holdings, one investor might build a cautious Narrative around heavy debt, slower reported revenue growth from asset sales and pressure on margins, leading to a lower Fair Value near US$35.91. Another might focus on AI data center demand, capital recycling and international expansion, arriving at a higher Fair Value near US$68.63. These two Narratives sit side by side so you can see exactly which assumptions you agree with.

    For GDS Holdings, we will make it really easy for you with previews of two leading GDS Holdings Narratives:

    🐂 GDS Holdings Bull Case

    Fair Value: US$53.72

    Implied discount to Fair Value at the last close of US$39.91: about 26%.

    Revenue growth assumption: 13.90% a year.

    • Focuses on large prepared power capacity in key Chinese markets and an expanding DayOne footprint in Southeast Asia and Europe as support for future AI and digital demand.

    • Highlights use of asset backed securities and C REITs to recycle capital and adjust leverage while keeping growth projects funded.

    • Flags risks around falling average pricing, continued reliance on asset sales, high net debt, delayed AI driven workloads and concentration in large cloud and internet customers.

    🐻 GDS Holdings Bear Case

    Fair Value: US$35.91

    Implied premium to Fair Value at the last close of US$39.91: about 11%.

    Revenue growth assumption: 11.74% a year.

    • Centers on high leverage, exposure to higher funding costs and slower reported revenue and EBITDA as more assets are moved into ABS and C REIT structures.

    • Points to pressure on average monthly service revenue per square meter, higher energy and compliance costs, and uncertainty from regulation, export controls and geopolitical tension.

    • Accepts that long term digital and AI demand, capital recycling options and international expansion could offset some of these pressures if they play out more favorably than expected.

    Do you think there’s more to the story for GDS Holdings? Head over to our Community to see what others are saying!

    NasdaqGM:GDS 1-Year Stock Price Chart
    NasdaqGM:GDS 1-Year Stock Price Chart

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include GDS.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

    Continue Reading

  • BYD Weighs Record Overseas Sales Against Domestic Slump And Battery Shift

    BYD Weighs Record Overseas Sales Against Domestic Slump And Battery Shift

    Never miss an important update on your stock portfolio and cut through the noise. Over 7 million investors trust Simply Wall St to stay informed where it matters for FREE.

    • BYD (SEHK:1211) reported a 65% jump in overseas unit sales in March, reaching its highest overseas volume in three months.

    • Domestic sales fell for the seventh consecutive month over the same period, highlighting a split between international and home market performance.

    • The company raised its export target for 2026, citing the role of higher oil prices and new international plants in supporting demand.

    • BYD also launched its first major battery upgrade in six years, a development that could influence buyer perception of its vehicles.

    For investors tracking BYD’s mix of growth drivers, the latest numbers underline the contrast between overseas traction and a weaker domestic backdrop. BYD, a major electric vehicle and battery producer, is relying more on global demand at a time when international buyers may be more sensitive to fuel prices and local production footprints.

    The new battery technology and higher export ambitions add fresh variables to watch beyond short term sales swings. The way these changes affect product appeal, pricing dynamics, and regional sales mix may help define the evolving risk profile and earnings quality story around BYD (SEHK:1211).

    Stay updated on the most important news stories for BYD by adding it to your watchlist or portfolio. Alternatively, explore our Community to discover new perspectives on BYD.

    SEHK:1211 1-Year Stock Price Chart

    See which insiders are buying and buying and selling BYD following this latest news.

    For existing and prospective shareholders, BYD’s record overseas sales in March sit against a recent full-year picture where sales reached CNY 803.96b while net income moved to CNY 32.62b and earnings per share dipped to CNY 3.58 from CNY 4.61. That mix, plus a lower proposed final dividend of RMB 0.358 per share, suggests the business is leaning harder on export growth and new technology, such as its first major battery upgrade in six years, at a time when domestic demand is under pressure. Market reaction to this combination of softer earnings, reduced cash returns and stronger export volumes can be a useful read on whether investors are prioritising growth optionality or capital return right now.

    • ⚠️ Pressure on earnings, with net income and EPS below the prior year, may keep some income focused investors cautious about the quality and resilience of profits.

    • ⚠️ A seventh month of weaker domestic sales, alongside a lower proposed dividend, may signal that management has less room to support shareholder payouts if the home market stays soft.

    • 🎁 Record overseas sales in March and a higher 2026 export target point to growing traction in international markets, which may diversify BYD’s revenue base away from China.

    • 🎁 The first major battery upgrade in six years could strengthen product appeal relative to other electric vehicle makers such as Tesla, NIO or XPeng if buyers respond positively to the new technology.

    From here, keep an eye on how quickly overseas volumes scale relative to ongoing domestic softness, and whether the new battery technology shows up in pricing power, order intake or regional sales mix. The progression from proposed to approved dividend later in 2026, and any commentary from the 2025 earnings call, can also help you judge how management is balancing reinvestment with shareholder returns.

    To ensure you’re always in the loop on how the latest news impacts the investment narrative for BYD, head to the community page for BYD to never miss an update on the top community narratives.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include 1211.HK.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

    Continue Reading

  • Amazon Globalstar Interest Puts Apple Satellite Story Under Fresh Review

    Amazon Globalstar Interest Puts Apple Satellite Story Under Fresh Review

    Get insights on thousands of stocks from the global community of over 7 million individual investors at Simply Wall St.

    • Amazon is exploring a potential acquisition of Globalstar, the satellite operator that underpins Apple’s Emergency SOS and other satellite features.

    • Apple, which holds a significant stake in Globalstar, currently relies on the company’s network to support satellite connectivity on selected iPhone models.

    • A change of control at Globalstar to another large tech company could affect how NasdaqGS:AAPL structures future device features and service agreements.

    For Apple, satellite connectivity has become part of the broader hardware and services story, alongside devices, wearables and digital subscriptions. The tie up with Globalstar helps support Emergency SOS and related services that Apple uses to differentiate certain iPhone models in a crowded smartphone market. In parallel, large technology groups are looking more closely at space based infrastructure as demand for always on connectivity expands.

    If Amazon proceeds with a Globalstar deal, investors in NasdaqGS:AAPL may focus on how Apple responds in terms of contract terms, network redundancy and control over key user experiences. The outcome could influence how Apple approaches future satellite partnerships, capital allocation to connectivity projects and the balance between in house capabilities and external providers over the long term.

    Stay updated on the most important news stories for Apple by adding it to your watchlist or portfolio. Alternatively, explore our Community to discover new perspectives on Apple.

    NasdaqGS:AAPL Earnings & Revenue Growth as at Apr 2026

    We’ve flagged 0 risks for Apple. See which could impact your investment.

    For Apple, Amazon’s interest in buying Globalstar goes straight to the heart of how it delivers emergency and satellite features on iPhone. Apple holds a 20% stake in Globalstar and has committed about US$1.5b to its infrastructure, so any ownership change to a large competitor in consumer tech is more than a routine supplier shuffle. Investors are likely to think about whether Apple can preserve priority access, service quality, and economics if Amazon gains control of Globalstar while also building its own satellite operation to rival services like SpaceX’s Starlink. This also sits alongside Apple’s broader approach of leaning on external partners in areas like AI models while keeping the user relationship and overall experience inside its own ecosystem.

    • The possible Globalstar sale fits the existing narrative that Apple uses partnerships to support hardware and services growth, since satellite connectivity has helped differentiate higher end iPhones and support its services story.

    • At the same time, the prospect of Amazon owning Globalstar challenges the idea that supply chain moves are mainly reducing dependence on powerful partners, because a key satellite provider could end up owned by a direct rival to Apple’s devices and services.

    • The current narrative places a lot of weight on AI partnerships and services expansion but does not fully spell out how control of space based connectivity, and a partner like Amazon entering that layer, might affect Apple’s long term bargaining power.

    Knowing what a company is worth starts with understanding its story. Check out one of the top narratives in the Simply Wall St Community for Apple to help decide what it’s worth to you.

    • ⚠️ If Amazon gains control of Globalstar, Apple could face tougher contract negotiations around capacity, pricing, and feature roadmaps for satellite services on iPhone compared with working with a standalone satellite partner.

    • ⚠️ A competitor such as Amazon controlling a critical connectivity layer may increase operational and concentration risk for Apple if there are service disruptions, conflicting priorities, or limited alternatives in the near term.

    • 🎁 Apple’s existing 20% equity stake and US$1.5b investment give it a formal voice in Globalstar deal discussions, which may help secure contract protections and maintain continuity for emergency and connectivity features.

    • 🎁 The scrutiny around this possible deal may prompt Apple to diversify satellite relationships or invest further in alternative connectivity options, which could reduce single partner risk over time.

    From here, keep an eye on any disclosure about Apple’s consent rights, long term capacity agreements, or change of control clauses if Amazon moves ahead with an offer for Globalstar. Watch for signals on whether Apple sticks with Globalstar under new ownership or starts flagging alternative partners or in house projects for satellite support. Commentary from other large players in connectivity, such as Alphabet and Microsoft, on space based infrastructure could also give context for how competitive this layer is becoming. Taken together, these details will help you judge how much control Apple keeps over a feature set that is increasingly tied to safety, reliability, and differentiation for premium devices.

    To ensure you’re always in the loop on how the latest news impacts the investment narrative for Apple, head to the community page for Apple to never miss an update on the top community narratives.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include AAPL.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

    Continue Reading

  • ‘Mass layoffs by email might be the new norm’ as Oracle lays off thousands that way

    ‘Mass layoffs by email might be the new norm’ as Oracle lays off thousands that way

    By Weston Blasi

    The cloud-computing and database company began cutting 30,000 jobs on Tuesday

    Oracle this week told some workers in the U.S. and India that their roles were being eliminated.

    Oracle Corp.’s mass layoffs on Tuesday were part of the company’s cost-cutting measures as it continues to build out expensive data centers for powering artificial intelligence.

    But one aspect of the mass layoffs – which were estimated to be as many as 30,000 people – was alerting workers over email at 6 a.m. Eastern that Tuesday would be their last day. It’s not clear if all 30,000 of the reported layoffs occurred on Tuesday, or if more are coming later in the year.

    “After careful consideration of Oracle’s current business needs, we have made the decision to eliminate your role,” an email to one affected employee, obtained by MarketWatch, read.

    Oracle (ORCL) employed an estimated 162,000 people worldwide as of May 2025, and has seen its stock falter this year. Shares of Oracle are down 4.3% over the past month, and down 25% year to date.

    Oracle declined to comment.

    While MarketWatch’s Charles Passy has noted that there’s no such thing as a good layoff, getting let go over email is starting to become a growing trend.

    “It’s not unheard of to lay workers off by email, especially in the tech industry and large corporations,” Peter Duris, CEO and co-founder of Kickresume, a career platform and resume-builder company, told MarketWatch. “There have been quite a few stories in recent years about major companies laying off large numbers of employees by email. Those messages are often described as cold, impersonal and vague about why a role is being cut.”

    Amazon (AMZN) made headlines earlier this year after its planned mass-layoff email was accidentally sent too early, and to the wrong employees.

    Tesla’s (TSLA) Elon Musk famously used “Dear Employee” emails to trim Tesla’s workforce starting in 2024. In that situation, even some bosses were unaware that layoffs were coming, one Tesla employee told MarketWatch in 2024.

    Google (GOOG) (GOOGL)also announced a headcount reduction over email back in 2024.

    While this process may seem impersonal, when really large companies conduct mass layoffs, this is one of the most efficient ways to let thousands of workers know they have been let go. Particularly if they are not all in one location.

    “Letting all these employees know at the same time creates much less administrative work,” Duris said. “This is especially the case when the workers being laid off are based all over the world, in multiple time zones.”

    “It also lets companies cut off access to work email and other platforms immediately after delivering the news, which may help prevent retaliation from angry employees,” he added.

    Besides email, we’ve also seen layoffs over Zoom (ZM) or video calls in recent years. And Duris doesn’t expect those types of layoffs to subside anytime soon.

    “Unfortunately, mass layoffs by email might be the new norm in the tech industry. Similarly, companies are telling employees they’ve lost their jobs over video calls, sometimes with the chat function disabled or with attendees unable to switch their microphones on… some people have even been fired by pre-recorded video messages, leaving them with no way to respond.”

    Read on: Here’s one reason investors shouldn’t get too excited about this week’s stock-market rebound

    -Weston Blasi

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal. 

    
  (END) Dow Jones Newswires
    

    
  04-04-26 1125ET
    

    Copyright (c) 2026 Dow Jones & Company, Inc.

    Continue Reading

  • April typically showers stock investors with gains – but this year is no sure bet

    April typically showers stock investors with gains – but this year is no sure bet

    By Mark Hulbert

    Between tax season and early sell-in-May activity, investors shouldn’t count on an April rally

    April may not be the cruelest month – but it is a riskier one.

    Some Wall Street analysts are insisting that April – contrary to its label as the cruelest month – is actually one of the better months for the U.S. stock market.

    Consider that, over the past century, the S&P 500 SPX (or its predecessor index) has gained 1.3% on average in April – close to double the all-month average of 0.7%. But, as the green columns in the chart below indicate, three other months post average returns on par with those of April (shown as No. 4 for the fourth month), with one month, July (or No. 7), significantly better.

    The chart also shows the first half of April being notably strong for stocks. That’s for at least two reasons, according to some of the newsletter editors I regularly monitor. One is the Federal Reserve’s desire to keep economywide liquidity stable at a time when taxpayers are sending potentially large sums to the IRS. Another is that taxpayers can reduce their tax burdens by investing in an IRA before April 15. Much of the additional liquidity and IRA contributions presumably make their way into the stock market.

    These are nice theories, but they are not borne out by the data, as the red columns in the chart show. So while April’s average first-half return is above average, it is not statistically significant.

    Season’s grating

    One caveat that investors should be aware of: April marks the end of the six-month period that is believed to have positive seasonality for stocks. April, therefore, is a month in which some investors look for opportunities to sell rather than wait until May (recall the adage “sell in May and go away”). Last year, for example, Jeffrey Hirsch of the Stock Trader’s Almanac and the Almanac Investor Newsletter, who recommends jumping the gun in this way, exited stocks on April 3 – almost a full month in advance of the usual sell date.

    The bottom line: You may want to remain invested in equities during April or even increase your holdings. If you do, though, it shouldn’t be because of the calendar. Given the year-to-year volatility in monthly returns, April’s advantage over other months is not significant at the 95% confidence level that statisticians often use to assess whether a pattern is genuine. That means it would be too risky for you to bet that April will be a good month for the stock market.

    Mark Hulbert is a regular contributor to MarketWatch. His Hulbert Ratings tracks investment newsletters that pay a flat fee to be audited. He can be reached at mark@hulbertratings.com

    More: A wild first quarter comes to an end: 6 charts that defined a chaotic stretch for stocks

    Also read: Stocks surge, ending a tough March on a high note. But there’s skepticism about the rally.

    -Mark Hulbert

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal. 

    
  (END) Dow Jones Newswires
    

    
  04-04-26 1112ET
    

    Copyright (c) 2026 Dow Jones & Company, Inc.

    Continue Reading

  • Risk of Intraoperative Periprosthetic Femoral Fracture According to Cementless Femoral Stem Geometry: A Cohort Study Based on the Radaelli Classification

    Risk of Intraoperative Periprosthetic Femoral Fracture According to Cementless Femoral Stem Geometry: A Cohort Study Based on the Radaelli Classification

    Continue Reading

  • These charts show the cracks in the stock market are widening

    These charts show the cracks in the stock market are widening

    By Lawrence G. McMillan

    S&P 500 technical indicators point to further weakening

    The S&P 500 Index SPX is in a downtrend and has broken multiple support levels. It finally closed below its -4 “modified Bollinger band,” which eventually set up a McMillan volatility band buy signal (green “B” on the SPX chart below).

    The McMillan volatility band buy signal will remain in effect until SPX reaches either its target (the +4 band) or closes below its stop (the -4 band). SPX did not close above 6,615 – the Chandelier stop for short sales (of the SPX). There is still resistance in the 6,615-6,670 area, including the declining 20-day moving average, the 200-day moving average, and resistance from earlier in March. The SPX chart remains in a downtrend.

    Equity-only put-call ratios continue to make new highs. The rate of ascent has slowed over the past two days as SPX has rallied, but these won’t be on buy signals until they roll over and begin to trend lower.

    On a more positive note, breadth was strong enough that both breadth oscillators are now on buy signals. Having said that, we’re going to wait until next week before possibly implementing this new buy signal.

    New lows still outnumber new highs on the NYSE, so this indicator remains bearish.

    The trend of VIX VIX sell signal (for stocks) remains in place. The construct of volatility derivatives retains a bearish outlook for stocks as well. Until that construct improves, we won’t be taking positions in line with the many VIX “spike peak” buy signals.

    In summary, the S&P 500’s oversold rally was sharp but appears to have ended short of the declining 20-day moving average. However, things are moving fast these days, so there could be surprises in either direction. We will take new signals as they occur, but with some caution.

    New recommendation: McMillan volatility band buy signal

    As noted above, a new McMillan volatility band buy signal has occurred. SPX closed below the -4 “modified Bollinger band” (mBB) several times, and then on March 31, it closed above the -3 mBB. This created a “classic” mBB buy signal, but we don’t trade those. Then on April 1, SPX continued to rally, and that confirmed the MVB buy signal

    Buy 1 SPY SPY (May 1) at-the-money call and Sell 1 SPY (May 1) call with a striking price 25 points higher.

    This position has a target of SPX trading at the +4 band. It would be stopped out if SPX were to close back below the -4 band.

    Watch H&R Block

    This is a repeat recommendation from last week. HRB (HRB) stock has been in a severe downtrend since last tax season ended. Recently though, the stock’s chart pattern formed a double-bottom and the shares are trying to break out over resistance at $32.50. Perhaps the 2026 tax season will be of some help, although one would have thought that would be already baked into the stock price. In any case, if HRB can indeed break out over $32.50 on a closing basis, then we will act on this put-call ratio buy signal.

    If HRB closes above $32.50, then buy 3 HRB (Apr. 17) 30 calls in line with the market.

    New recommendation: SFL Corp.

    Option prices on SFL (SFL) are relatively cheap, especially those of intermediate-term duration. This is the kind of situation in which we like to buy straddles – buying both a put and call. Then, if the stock makes a large enough move in either direction, we can profit.

    This stock has recently rallied from below $7 to above $11. That four-point move took about four months. Other four-month periods have produced similarly large moves (see the accompanying chart of SFL). This week the five-month straddle was priced at about $1.75. That’s what makes these options relatively cheap and sets the stage for a profit if the stock continues to move as it has in the past.

    Buy 4 SFL (Aug. 21) 10 calls and Buy 4 SFL (Aug. 21) 10 puts at a straddle price of $1.75 or less.

    Follow-up action:

    All stops are mental closing stops unless otherwise noted.

    We are using a standard rolling procedure for our SPY spreads: In any vertical bull or bear spread, if the underlying hits the short strike, then roll the entire spread. That would be roll up in the case of a call bull spread or roll down in the case of a bear put spread. Stay in the same expiration and keep the distance between the strikes the same unless otherwise instructed.

    Also, for outright long options, roll if they become 8 points in-the-money.

    Long 1 TSEM (April 17) 190 call and short 1 TSEM (April 17) 205 call: Roll up and out both sides, 15 points each, if TSEM (TSEM) trades at 205.

    Long 6 AAL (April 17) 10.5 puts: Sell these AAL (AAL) puts now since the put-call ratio has rolled over to a buy signal.

    Long 1 BKR (July 17) 65 call and long 1 BKR (July 17) 60 put: Roll the BKR (BKR) call up at 75 and roll the put down at 50.

    Long 2 ARKK (April 17) 74 calls: We will hold the calls as long as the weighted put-call ratio for ARKK ARKK remains on a buy signal.

    Long Buy 2 SPY (April 17) 666 puts and short 2 SPY (April 17) 615: Use a close back above 6,615 by SPX as a trailing stop.

    Long 2 KMX (April 17) 42.5 puts: We will hold as long as the weighted put-call ratio for CarMax (KMX) remains on a sell signal.

    All stops are mental closing stops unless otherwise noted.

    Send questions to: lmcmillan@optionstrategist.com.

    Lawrence G. McMillan is president of McMillan Analysis, a registered investment and commodity trading advisor. McMillan may hold positions in securities recommended in this report, both personally and in client accounts. He is an experienced trader and money manager and is the author of “Options as a Strategic Investment.” www.optionstrategist.com

    (c)McMillan Analysis Corporation is registered with the SEC as an investment advisor and with the CFTC as a commodity trading advisor. The information in this newsletter has been carefully compiled from sources believed to be reliable, but accuracy and completeness are not guaranteed. The officers or directors of McMillan Analysis Corporation, or accounts managed by such persons may have positions in the securities recommended in the advisory.

    -Lawrence G. McMillan

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal. 

    
  (END) Dow Jones Newswires
    

    
  04-04-26 0924ET
    

    Copyright (c) 2026 Dow Jones & Company, Inc.

    Continue Reading

  • This Week in Climate News (April 2026, Week 1)

    This Week in Climate News (April 2026, Week 1)

    This weekly round-up brings you key climate news from the past seven days, including new data on the rapid growth of renewables and a controversial panel’s vote to facilitate the Trump administration’s expansion of drilling activity in the Gulf of Mexico.

    —

    Listen to Earth.Org’s new podcast, Earth Radio. Join our host Rebekah Hendricks every week for a 5-minute, ad-free roundup of the world’s most important climate stories. New episodes available every Saturday at 8am ET | 1pm GMT | 8pm HKT⁠. Subscribe here or find us wherever you get your podcasts.

    1. Renewables Hit Nearly Half of Global Power Capacity in 2025

    Renewable energy accounted for nearly half of global power capacity by the end of 2025, according to new data from the International Renewable Energy Agency (IRENA).

    Last year saw the largest-ever recorded increase in renewable energy capacity – a 15.5% annual increase, or 692 gigawatts (GW) of added renewable capacity, the agency said in a report published on Wednesday. This continues a trend that has seen renewable power additions reaching new records almost every year since the turn of the millennium owing to their “competitiveness and resilience,” said Francesco La Camera, IRENA’s Director-General.

    Renewables accounted for 49% of installed power capacity globally and comprised 85.6% of the total global power added in 2025. Driving this growth was solar energy, which alone accounted for nearly three-quarters of all renewable additions – a record 510 GW. Wind came in second, with 159 GW added in one year.

    Full story here.

    2. Trump Administration Officials Waive Endangered Species Act Rules for Gulf Drilling

    A panel comprised of Trump Administration officials on Tuesday approved an exemption from the Endangered Species Act for expanded oil and gas drilling in the Gulf of Mexico. 

    Last month, the Pentagon requested that Interior Secretary Doug Burgum convenes a meeting with the Endangered Species Committee to discuss an exemption from the Endangered Species Act for “all … oil and gas exploration and development activities” overseen by federal agencies in the Gulf of Mexico over “national security” concerns. Since its inception in 1973, the law, which requires federal agencies to ensure their actions do not jeopardize endangered species or destroy critical habitats, has prevented the extinction of 99% of listed species.

    On Tuesday, the committee, also known as the “God squad” for its power to decide whether a species lives or dies, approved the request after a 20-minute, closed-door meeting.

    The committee only met three times since Congress established it in 1978, the last time in 1992. It is led by the Interior Secretary and comprises five other federal officials: the Secretary of Agriculture, the Secretary of the Army, the Chairman of the Council of Economic Advisors, the Administrator of the Environmental Protection Agency, and the Administrator of the National Oceanic and Atmospheric Administration.

    Full story here.

    3. Health, Environmental Groups Sue US EPA Over Rollback of Mercury Standards for Power Plants

    A coalition of US-based health and environmental groups is taking the Environmental Protection Agency (EPA) to court over its recent repeal of standards that limit brain-damaging mercury, lead, and other hazardous air pollution from coal-fired power plants.

    The suit addresses the EPA’s repeal of the Biden-era amendments to the Mercury and Air Toxics Standards (MATS), which was finalized in February. The repeal effectively allows coal-fired power plants to emit more brain-damaging mercury and other harmful heavy metals such as nickel, arsenic, and lead.

    The lawsuit also challenges the repeal of a requirement for power plants to have systems in place to monitor the amount of pollution they emit in accordance with air pollution standards.

    The standards, first issued in 2012 by the Obama administration, were strengthened and updated by the Biden administration in April 2024 to reflect the latest advancements in pollution control technologies. Since 2015, the deadline for their implementation, the standards have delivered a 90% reduction in mercury emissions from power plants over pre-standard levels and other health benefits, including lowered risk of cancer, heart and lung disease, and premature death. According to EPA figures cited in the coalition’s press release announcing the lawsuit, 93% of US coal capacity had already met or were on track to meet those standards by last year.

    Full story here.

    4. Italy Votes to Delay Shutdown of Coal-Fired Plants By 13 Years As Energy Crunch Deepens Amid Iran War

    Italy is set to postpone the shutdown of its remaining coal-fired power plants until 2038, 13 years later than originally planned, as the global energy crisis unleashed by the US-Israeli attacks on Iran intensifies.

    On Tuesday, the lower house of parliament voted to extend the life of the country’s four remaining coal-powered plants, which are currently on stand-by. The National Energy and Climate Plan, a ten-year plan provided by the European Union (EU) to member states to meet the EU’s decarbonization goals, had initially envisaged a shutdown by December 2025.

    The text, promoted by Prime Minister Giorgia Meloni’s right-wing government coalition, now goes to the upper house, where it expected to pass.

    Supporters of the text, including the right-wing populist League party, said it was “right and responsible” to delay the shutdown amid the “serious international energy crisis” unleashed by the war in Iran. In response to coordinated attacks by the US and Isreael, Iran blocked traffic in the Strait of Hormuz, one of the world’s busiest oil shipping channels. Some 20-25% of global oil supply typically passes through it, and Italy depends on the passage for about 21% of its total oil and gas imports.

    But environmentalists say the move will harm climate progress in the country and affect people’s health. Coal, the cheapest and dirtiest fossil fuel, is the single-largest source of global carbon emissions and a major contributor to air pollution.

    Full story here.

    Donate to earth.org; support independent environmental journalism

    Continue Reading

  • Hackers Are Posting the Claude Code Leak With Bonus Malware

    Hackers Are Posting the Claude Code Leak With Bonus Malware

    A WIRED investigation based on Department of Homeland Security records this week revealed the identities of paramilitary Border Patrol agents who frequently used force against civilians during Operation Midway Blitz in Chicago last fall. Several of the agents, WIRED found, appeared in similar operations in other states around the US.

    Customs and Border Protection may want to remember to protect its sensitive facility information. Using basic Google searches, WIRED discovered flashcards made by users of the online learning platform Quizlet that contained gate codes to CBP facilities and more.

    In a rare move, Apple this week released “backported” patches for iOS 18 to protect millions of people still using the older operating system from the DarkSword hacking technique that was found in use in the wild. Discovered in March, DarkSword allows attackers to infect iPhones that simply visit a website loaded with the takeover tools embedded in it. Apple initially pushed users to update to the current version of its operating system, iOS 26, but ultimately issued the iOS 18 patches after DarkSword continued to spread.

    The US-Israel war with Iran careened into its second month this week, with Iran threatening to launch attacks against more than a dozen US companies, including tech giants like Apple, Google, and Microsoft, which have offices and data centers in the Gulf region. The deadly conflict, which has no clear end in sight, continues to wreak havoc on the global economy as shipping crews remain stranded in the Strait of Hormuz, a key trade route. Meanwhile, some are beginning to wonder what could happen if US strikes cause real damage to Iran’s nuclear facilities.

    And that’s not all! Each week, we round up the security and privacy news we didn’t cover in depth ourselves. Click the headlines to read the full stories. And stay safe out there.

    Earlier this week, a security researcher flagged that Anthropic accidentally made the source code for its popular vibe-coding tool, Claude Code, public. Immediately, people began reposting the code on the developer platform GitHub. But beware if you want to try to download some of those repos yourself: BleepingComputer reports that some of the posters are actually hackers who have tucked a piece of infostealer malware into the lines of code.

    Anthropic, for its part, has been trying to remove copies of the leak (malware-ridden or not) by issuing copyright takedown notices. The Wall Street Journal reported that the company initially tried to remove more than 8,000 repositories on GitHub but later narrowed that down to 96 copies and adaptations.

    This isn’t the first time that hackers have capitalized on interest in Claude Code, which requires users who might not be as familiar with their computer’s terminal to copy and paste install commands from a website. In March, 404 Media reported that sponsored ads on Google led to sites that were masquerading as official Claude Code installation guides, which directed users to run a command that would actually download malware.

    The FBI formally classified a recent cyber intrusion into one of its surveillance collection systems as a “major incident” under FISMA—a legal designation reserved for breaches believed to pose serious risks to national security. The determination, reported to Congress earlier this week, is understood to be the first time since at least 2020 that the bureau has declared a major incident on its own systems. Politico, citing two unnamed senior Trump administration officials, reported that China is believed to be behind the intrusion. If confirmed, the breach could mark a significant counterintelligence failure for the FBI.

    The FBI said it detected “suspicious activities” on its networks in February. In a notice to Congress on March 4, reviewed by Politico, the bureau said the compromised systems were unclassified and held “returns from legal process,” citing, as examples, phone and internet metadata collected under court orders and personal information “pertaining to subjects of FBI investigations.” The intruders reportedly gained access through a commercial internet service provider, an approach the FBI characterized as reflecting “sophisticated tactics.” In its only public statement, the bureau said it had deployed “all technical capabilities to respond.”

    Continue Reading