Category: 3. Business

  • Devi, N. S. et al. Overview of antimicrobial resistance and mechanisms: The relative status of the past and current. Microbe 3, 100083 (2024).

    Article 

    Google Scholar 

  • Smith, W. P. J., Wucher, B. R., Nadell, C. D. & Foster, K. R. Bacterial defences: mechanisms, evolution and antimicrobial resistance. Nat. Rev. Microbiol. 21, 519–534 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Darby, E. M. et al. Molecular mechanisms of antibiotic resistance revisited. Nat. Rev. Microbiol. 21, 280–295 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Rosas, N. C. & Lithgow, T. Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance. Trends Microbiol. 30, 544–552 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mansilla, M. C. & Mendoza, D. D. Regulation of Membrane Lipid Homeostasis in Bacteria upon Temperature Change. In Biogenesis of Fatty Acids, Lipids and Membranes. Handbook of Hydrocarbon and Lipid Microbiology. (eds Geiger, O.) pp.1–13, (Springer, Cham, 2016).

  • Chwastek, G. et al. Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling. Cell Rep. 32, 108165 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Agmon, E. & Stockwell, B. R. Lipid homeostasis and regulated cell death. Curr. Opin. Chem. Biol. 39, 83–89 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Winnikoff, J. R. et al. Homeocurvature adaptation of phospholipids to pressure in deep-sea invertebrates. Science. (N. Y., N. Y.) 384, 1482–1488 (2024).

    Article 
    CAS 

    Google Scholar 

  • Wood, J. M. Bacterial responses to osmotic challenges. J. Gen. Physiol. 145, 381–388 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Malanovic, N. & Lohner, K. Antimicrobial Peptides Targeting Gram-Positive Bacteria. Pharmaceuticals (Basel, Switzerland) 9, 59 (2016).

  • Malanovic, N. & Lohner, K. Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides. Biochimica et. biophysica acta. 1858, 936–946 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Khondker, A. & Rheinstädter, M. C. How do bacterial membranes resist polymyxin antibiotics? Commun. Biol. 3, 77 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Global burden of bacterial antimicrobial resistance in 2019 a systematic analysis. Lancet (Lond., Engl.) 399, 629–655 (2022).

    Article 

    Google Scholar 

  • Hoenigl, M. et al. COVID-19-associated fungal infections. Nat. Microbiol. 7, 1127–1140 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Shafran, N. et al. Secondary bacterial infection in COVID-19 patients is a stronger predictor for death compared to influenza patients. Sci. Rep. 11, 12703 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Galeano Niño, J. L. et al. Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer. Nature 611, 810–817 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Malanovic, N. & Vejzovic, D. Novel insights at the crossroads of antibiotic use and cancer risk. Cell stress 7, 46–49 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Narunsky-Haziza, L. et al. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell 185, 3789–3806.e17 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sinha, G. Tumors can teem with microbes. But what are they doing there? Sci. (N. Y., N. Y.) 378, 693–694 (2022).

    Article 

    Google Scholar 

  • Malanovic, N. et al. Disruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria. Appl. Environ. Microbiol. 88, 10.e0018022 (2022).

  • Malanovic, N., Ön, A., Pabst, G., Zellner, A. & Lohner, K. Octenidine: Novel insights into the detailed killing mechanism of Gram-negative bacteria at a cellular and molecular level. Int. J. antimicrobial agents 56, 106146 (2020).

    Article 
    CAS 

    Google Scholar 

  • Vejzovic, D., Iftic, A., Ön, A., Semeraro, E. F. & Malanovic, N. Octenidine’s Efficacy: A Matter of Interpretation or the Influence of Experimental Setups? Antibiotics (Basel, Switzerland) 11, 1665 (2022).

  • Dhoonmoon, L. & Malanovic, N. Enhancing patient outcomes: the role of octenidine-based irrigation solutions in managing sore and irritated peristomal skin. J. wound care 34, S4–S11 (2025).

    Article 
    PubMed 

    Google Scholar 

  • Bock, L. J. et al. Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling. Commun. Biol. 4, 1058 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lescat, M., Magnan, M., Kenmoe, S., Nordmann, P. & Poirel, L. Co-Lateral Effect of Octenidine, Chlorhexidine and Colistin Selective Pressures on Four Enterobacterial Species: A Comparative Genomic Analysis. Antibiotics (Basel, Switzerland) 11, 50 (2021).

  • Dijksteel, G. S., Ulrich, M. M. W., Middelkoop, E. & Boekema, B. K. H. L. Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs). Front. Microbiol. 12, 616979 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ridyard, K. E. & Overhage, J. The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent. Antibiotics (Basel, Switzerland) 10, 650 (2021).

  • de Breij, A. et al. The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Sci. Transl. Med. 10, 423 (2018).

  • Malanovic, N., Marx, L., Blondelle, S. E., Pabst, G. & Semeraro, E. F. Experimental concepts for linking the biological activities of antimicrobial peptides to their molecular modes of action. Biochimica et. biophysica acta Biomembranes 1862, 183275 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Piller, P. et al. Membrane Activity of LL-37 Derived Antimicrobial Peptides against Enterococcus hirae: Superiority of SAAP-148 over OP-145. Biomolecules 12, 523 (2022).

  • Ön, A. et al. Bactericidal Activity to Escherichia coli: Different Modes of Action of Two 24-Mer Peptides SAAP-148 and OP-145, Both Derived from Human Cathelicidine LL-37. Antibiotics (Basel, Switzerland) 12, 1163 (2023).

  • Vejzovic, D. et al. Where Electrostatics Matter: Bacterial Surface Neutralization and Membrane Disruption by Antimicrobial Peptides SAAP-148 and OP-145. Biomolecules 12, 1252 (2022).

  • Wenzel, M. et al. Small cationic antimicrobial peptides delocalize peripheral membrane proteins. Proc. Natl. Acad. Sci. USA 111, E1409–E1418 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Butler, M. S., Henderson, I. R., Capon, R. J. & Blaskovich, M. A. T. Antibiotics in the clinical pipeline as of December 2022. J. Antibiotics 76, 431–473 (2023).

    Article 
    CAS 

    Google Scholar 

  • Zhang, H.-Q., Sun, C., Xu, N. & Liu, W. The current landscape of the antimicrobial peptide melittin and its therapeutic potential. Front. Immunol. 15, 1326033 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kahlenberg, J. M. & Kaplan, M. J. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J. Immunol. (Baltim., Md.: 1950) 191, 4895–4901 (2013).

    Article 
    CAS 

    Google Scholar 

  • Yang, L., Harroun, T. A., Weiss, T. M., Ding, L. & Huang, H. W. Barrel-stave model or toroidal model? A case study on melittin pores. Biophysical J. 81, 1475–1485 (2001).

    Article 

    Google Scholar 

  • Oren, Z., Lerman, J. C., Gudmundsson, G. H., Agerberth, B. & Shai, Y. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. Biochemical J. 341, 501–513 (1999).

  • Lee, C.-C., Sun, Y., Qian, S. & Huang, H. W. Transmembrane pores formed by human antimicrobial peptide LL-37. Biophysical J. 100, 1688–1696 (2011).

    Article 
    CAS 

    Google Scholar 

  • Yang, Z., Choi, H. & Weisshaar, J. C. Melittin-Induced Permeabilization, Re-sealing, and Re-permeabilization of E. coli Membranes. Biophysical J. 114, 368–379 (2018).

    Article 
    CAS 

    Google Scholar 

  • Sancho-Vaello, E. et al. The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics. Sci. Rep. 10, 17356 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Majewska, M., Zamlynny, V., Pieta, I. S., Nowakowski, R. & Pieta, P. Interaction of LL-37 human cathelicidin peptide with a model microbial-like lipid membrane. Bioelectrochemistry (Amst., Neth.) 141, 107842 (2021).

    Article 
    CAS 

    Google Scholar 

  • Hong, J. et al. How Melittin Inserts into Cell Membrane: Conformational Changes, Inter-Peptide Cooperation, and Disturbance on the Membrane. Molecules (Basel, Switzerland) 24, 1775 (2019).

  • Porcelli, F. et al. NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry 47, 5565–5572 (2008).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sevcsik, E., Pabst, G., Jilek, A. & Lohner, K. How lipids influence the mode of action of membrane-active peptides. Biochimica et. biophysica acta. 1768, 2586–2595 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sevcsik, E. et al. Interaction of LL-37 with model membrane systems of different complexity: influence of the lipid matrix. Biophysical J. 94, 4688–4699 (2008).

    Article 
    CAS 

    Google Scholar 

  • van den Bogaart, G., Mika, J. T., Krasnikov, V. & Poolman, B. The lipid dependence of melittin action investigated by dual-color fluorescence burst analysis. Biophysical J. 93, 154–163 (2007).

    Article 

    Google Scholar 

  • Sochacki, K. A., Barns, K. J., Bucki, R. & Weisshaar, J. C. Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37. Proc. Natl. Acad. Sci. USA 108, E77–E81 (2011).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • White, J. K. et al. A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens. Cell. Mol. life Sci. : CMLS 79, 411 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Strömstedt, A. A., Wessman, P., Ringstad, L., Edwards, K. & Malmsten, M. Effect of lipid headgroup composition on the interaction between melittin and lipid bilayers. J. Colloid Interface Sci. 311, 59–69 (2007).

    Article 
    PubMed 

    Google Scholar 

  • Ulmschneider, J. P. & Ulmschneider, M. B. Melittin can permeabilize membranes via large transient pores. Nat. Commun. 15, 7281 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sohlenkamp, C. & Geiger, O. Bacterial membrane lipids: diversity in structures and pathways. FEMS Microbiol. Rev. 40, 133–159 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Savini, F. et al. Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components. Biochimica et. biophysica acta Biomembranes 1862, 183291 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Gunasekera, S., Muhammad, T., Strömstedt, A. A., Rosengren, K. J. & Göransson, U. Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability. Front. Microbiol. 11, 168 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Juhaniewicz-Debinska, J. Melittin-Induced Structural Transformations in DMPG and DMPS Lipid Membranes: A Langmuir Monolayer and AFM Study. Molecules (Basel, Switzerland) 29, 6064 (2024).

  • Abramson, J. et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature 630, 493–500 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Scheenstra, M. R. et al. Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Sci. Rep. 9, 4780 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Te Winkel, J. D., Gray, D. A., Seistrup, K. H., Hamoen, L. W. & Strahl, H. Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes. Front. Cell Dev. Biol. 4, 29 (2016).

    Article 

    Google Scholar 

  • Cantón, R. & Morosini, M.-I. Emergence and spread of antibiotic resistance following exposure to antibiotics. FEMS Microbiol. Rev. 35, 977–991 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Kowalska-Krochmal, B. & Dudek-Wicher, R. The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance. Pathogens (Basel, Switzerland) 10, 165 (2021).

  • O’Neill, A. J. & Chopra, I. Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques. Expert Opin. investigational drugs 13, 1045–1063 (2004).

    Article 

    Google Scholar 

  • Loffredo, M. R. et al. Inoculum effect of antimicrobial peptides. Proc. Natl. Acad. Sci. USA. 118, e2014364118 (2021).

  • Oliver, P. M. et al. Localization of anionic phospholipids in Escherichia coli cells. J. Bacteriol. 196, 3386–3398 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pandidan, S. & Mechler, A. Nano-viscosimetry analysis of the membrane disrupting action of the bee venom peptide melittin. Sci. Rep. 9, 10841 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wimley, W. C. How Does Melittin Permeabilize Membranes? Biophysical J. 114, 251–253 (2018).

    Article 
    CAS 

    Google Scholar 

  • Papo, N. & Shai, Y. Exploring peptide membrane interaction using surface plasmon resonance: differentiation between pore formation versus membrane disruption by lytic peptides. Biochemistry 42, 458–466 (2003).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ramírez-Montiel, F. et al. Plasma membrane damage repair is mediated by an acid sphingomyelinase in Entamoeba histolytica. PLoS Pathog. 15, e1008016 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Blazek, A. D., Paleo, B. J. & Weisleder, N. Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis. Physiol. (Bethesda, Md.) 30, 438–448 (2015).

    CAS 

    Google Scholar 

  • Daussy, C. F. & Wodrich, H. “Repair Me if You Can”: Membrane Damage, Response, and Control from the Viral Perspective. Cells 9, 2042 (2020).

  • Lee, M.-T., Sun, T.-L., Hung, W.-C. & Huang, H. W. Process of inducing pores in membranes by melittin. Proc. Natl. Acad. Sci. USA 110, 14243–14248 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kamiura, R., Matsuda, F. & Ichihashi, N. Survival of membrane-damaged Escherichia coli in a cytosol-mimicking solution. J. Biosci. Bioeng. 128, 558–563 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sreepadmanabh, M. et al. Cell shape affects bacterial colony growth under physical confinement. Nat. Commun. 15, 9561 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Trinh, K. T. L. & Lee, N. Y. Recent Methods for the Viability Assessment of Bacterial Pathogens: Advances, Challenges, and Future Perspectives. Pathogens (Basel, Switzerland) 11, 1057 (2022).

  • Lempp, M., Lubrano, P., Bange, G. & Link, H. Metabolism of non-growing bacteria. Biol. Chem. 401, 1479–1485 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zamaraeva, M. V. et al. Cells die with increased cytosolic ATP during apoptosis: a bioluminescence study with intracellular luciferase. Cell Death Differ. 12, 1390–1397 (2005).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Farha, M. A., Verschoor, C. P., Bowdish, D. & Brown, E. D. Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus. Chem. Biol. 20, 1168–1178 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Choi, H., Yang, Z. & Weisshaar, J. C. Oxidative stress induced in E. coli by the human antimicrobial peptide LL-37. PLoS Pathog. 13, e1006481 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhu, Y., Mohapatra, S. & Weisshaar, J. C. Rigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopy. Proc. Natl. Acad. Sci. USA 116, 1017–1026 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sani, M.-A., Henriques, S. T., Weber, D. & Separovic, F. Bacteria May Cope Differently from Similar Membrane Damage Caused by the Australian Tree Frog Antimicrobial Peptide Maculatin 1.1. J. Biol. Chem. 290, 19853–19862 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Separovic, F., Hofferek, V., Duff, A. P., McConville, M. J. & Sani, M.-A. In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide. J. Struct. Biol.: X 6, 100074 (2022).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nell, M. J. et al. Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application. Peptides 27, 649–660 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Malanovic, N. et al. S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis. J. Biol. Chem. 283, 23989–23999 (2008).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zegarlińska, J., Piaścik, M., Sikorski, A. F. & Czogalla, A. Phosphatidic acid – a simple phospholipid with multiple faces. Acta biochimica Polonica 65, 163–171 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Kulig, W. et al. Complex Behavior of Phosphatidylcholine-Phosphatidic Acid Bilayers and Monolayers: Effect of Acyl Chain Unsaturation. Langmuir: ACS J. Surf. colloids 35, 5944–5956 (2019).

    Article 
    CAS 

    Google Scholar 

  • Eaton, J. M. et al. Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation. J. Biol. Chem. 289, 18055–18066 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bechinger, B. The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy. Biochimica et. biophysica acta. 1462, 157–183 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Batenburg, A. M. et al. Interaction of melittin with negatively charged phospholipids: consequences for lipid organization. FEBS Lett. 223, 148–154 (1987).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wang, X. et al. Analyzing mechanisms of action of antimicrobial peptides on bacterial membranes requires multiple complimentary assays and different bacterial strains. Biochimica et. biophysica acta Biomembranes. 1865, 184160 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Agrawal, A., Rangarajan, N. & Weisshaar, J. C. Resistance of early stationary phase E. coli to membrane permeabilization by the antimicrobial peptide Cecropin A. Biochimica et. biophysica acta Biomembranes 1861, 182990 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tan, B. K. et al. Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. Proc. Natl. Acad. Sci. USA 109, 16504–16509 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Domadia, P. N., Bhunia, A., Ramamoorthy, A. & Bhattacharjya, S. Structure, interactions, and antibacterial activities of MSI-594 derived mutant peptide MSI-594F5A in lipopolysaccharide micelles: role of the helical hairpin conformation in outer-membrane permeabilization. J. Am. Chem. Soc. 132, 18417–18428 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chitolie, M. S. & Toescu, E. C. High-throughput method for dynamic measurements of cellular viability using a BMG LABTECH microplate reader. The BMG LABTECH (2008).

  • Crowley, L. C. et al. Measuring Cell Death by Propidium Iodide Uptake and Flow Cytometry. Cold Spring Harb. protoc. 2016, https://doi.org/10.1101/pdb.prot087163 (2016).

  • Scheinpflug, K. et al. Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis. Sci. Rep. 7, 44332 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

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  • Stock market today: Live updates

    Stock market today: Live updates

    Traders work on the floor of the New York Stock Exchange during morning trading on March 30, 2026 in New York City.

    Michael M. Santiago | Getty Images

    U.S. stock futures fell on Thursday morning after President Donald Trump indicated that the Iran war would continue.

    S&P 500 futures declined 1.26%, and Nasdaq 100 futures lost 1.63%. Futures tied to the Dow Jones Industrial Average slid 507 points, or about 1.08%.

    Trump delivered an address Wednesday night, providing updates on the Middle East conflict. Though he said that the U.S. is “getting very close” to ending the Iran war, Trump added that the nation would “hit” Tehran “extremely hard.”

    “Over the next two to three weeks, we’re going to bring them back to the stone ages where they belong,” the president said.

    Stock futures slid during the speech, and oil prices surged. West Texas Intermediate crude futures were last up 3.5% at more than $103 a barrel, while Brent crude futures advanced more than 4% to top $105. At one point in the evening, Brent briefly hit $106 a barrel.

    All three major indexes advanced in regular trading Wednesday, as investors became more optimistic that the end of the U.S.-Iran war was in sight. The S&P 500 and Nasdaq Composite respectively gained 0.72% and 1.16%. The Dow rose 224.23 points, or 0.48%.

    In a Truth Social post on Wednesday morning, Trump said that Iran’s president had asked the U.S. for a ceasefire. However, Trump said that the U.S. would only “consider” the offer once the Straight of Hormuz was “open, free, and clear.”

    The announcement came after the president told reporters at the White House on Tuesday afternoon that he expects U.S. military forces will leave Iran in “two or three weeks.”

    “We don’t know how long this is going to last, but as market participants we need to understand the damage that has already been done,” Sebastien Page, head of global multi-asset and CIO at T. Rowe Price, said on CNBC’s “Closing Bell: Overtime” on Wednesday afternoon. “I don’t think we stabilize quickly back to normal levels of inflation. It’s a slow-moving macroeconomic chain.”

    “You have this background of still a robust economy, but you have to worry you’re on the knife’s edge for a growth shock,” Page added.

    Thursday marks the last trading day of the shortened week, as markets are closed for Good Friday. On Thursday morning traders will watch out for initial jobless claims for the week ending March 28, while March’s jobs report is set for release on Friday morning.

    —CNBC’s Spencer Kimball contributed reporting.

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  • IBM Announces Strategic Collaboration with Arm to Shape the Future of Enterprise Computing

    IBM Announces Strategic Collaboration with Arm to Shape the Future of Enterprise Computing

    Collaboration aims to advance new technologies that expand infrastructure choice while preserving mission-critical environments

    Apr 2, 2026

    ARMONK, N.Y., April 2, 2026 /PRNewswire/ — IBM (NYSE: IBM) today announced a strategic collaboration with Arm to develop new dual‑architecture hardware that helps enterprises run future AI and data intensive workloads with greater flexibility, reliability, and security.

    IBM Corporation logo. (PRNewsfoto/IBM Corporation)

    IBM’s leadership in system design, from silicon to software and security, has helped enterprises adopt emerging technologies with the scale and reliability required for mission‑critical workloads. As AI moves deeper into core business operations, IBM continues to invest in hardware platforms such as the Telum II processor and Spyre Accelerator, which are designed to bring AI from experimentation into everyday enterprise use.

    Through this collaboration, IBM and Arm aim to extend this track record of innovation by combining IBM’s enterprise leadership in systems reliability, security, and scalability with Arm’s own leadership in power‑efficient architecture, workload enablement expertise, and broad software ecosystem, to build flexible and scalable computing platforms for the future.

    “As enterprises scale AI and modernize their infrastructure, the breadth of the Arm software ecosystem is enabling these workloads to run across a broader range of environments,” said Mohamed Awad, Executive Vice President, Cloud AI Business Unit, Arm. “Our collaboration with IBM builds on this progress, extending the Arm ecosystem into mission-critical enterprise environments and giving organizations greater flexibility in how they deploy and scale these workloads.”

    “This collaboration is a natural extension of IBM’s leadership in hardware and systems innovation,” said Tina Tarquinio, Chief Product Officer, IBM Z and LinuxONE. “It continues IBM’s pattern of anticipating enterprise needs well ahead of market inflection points—developing capabilities early so clients are prepared as new workloads and business models emerge. Our aim is to expand software choice and improve system performance while maintaining the reliability and security our clients expect.”

    “Enterprise infrastructure is entering a new phase where flexibility, workload portability, and ecosystem reach are becoming just as critical as performance and reliability. As AI and data-intensive applications reshape requirements, organizations are looking for platforms that can evolve without forcing disruptive tradeoffs,” said Patrick Moorhead, Founder, CEO, and Chief Analyst at Moor Insights & Strategy. “What IBM and Arm are signaling here is a meaningful step toward that future that could broaden how enterprises think about deploying and scaling modern workloads. While the full implications will take time to unfold, it’s clear this reflects a deeper level of investment in long-term platform innovation and ecosystem expansion than we typically see at this stage.”

    A Collaboration Designed for What’s Next

    The collaboration is focused on three key areas. First, the companies are exploring how to expand virtualization technologies that allow Arm®-based software environments to operate within IBM’s enterprise computing platforms. This work is designed to expand software compatibility and further streamline how developers and enterprises bring Arm applications into mission-critical environments.

    Secondly, enterprise infrastructure must support high-availability operations, as well as security and local data sovereignty requirements. IBM and Arm are exploring new ways to support the performance and efficiency demands of modern workloads, including AI and data intensive applications. The work includes enabling enterprise systems to recognize and execute Arm applications, with the goal of helping Arm-based environments align with the reliability, security, and operational requirements enterprises need.

    Finally, the collaboration is focused on long term ecosystem growth. By creating shared technology layers between platforms, IBM and Arm aim to open the door to broader software ecosystems and greater flexibility in how applications are deployed and managed. This approach could give enterprises more choice, positioning them to adopt new applications and architectures while continuing to leverage their existing investments.

    “IBM’s defining role in shaping enterprise infrastructure spans decades, showcasing the breadth and commitment required to support our clients’ most intensive and sensitive workloads,” said Christian Jacobi, Chief Technology Officer and IBM Fellow, IBM Systems Development. “This moment marks the latest step in our innovation journey for future generations of our IBM Z and LinuxONE systems, reinforcing our end-to-end system design as a powerful advantage.”

    Statements regarding IBM’s future direction and intent are subject to change or withdrawal without notice, and represent goals and objectives only.

    About IBM

    IBM is a leading provider of global hybrid cloud and AI, and consulting expertise. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Thousands of governments and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to effect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and consulting deliver open and flexible options to our clients. All of this is backed by IBM’s long-standing commitment to trust, transparency, responsibility, inclusivity and service. Visit www.ibm.com for more information.

    Media contact:

    Bethany McCarthy

    IBM

    bethany@ibm.com

    SOURCE IBM

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  • US readies new pharmaceutical tariffs – Financial Times

    1. US readies new pharmaceutical tariffs  Financial Times
    2. Trump administration readies new tariffs on select drugmakers, Bloomberg News reports  reuters.com
    3. US preparing 100% pharmaceutical tariffs- FT  investing.com
    4. Trump Signs Drug Price Order and Escalates Tariffs as White House Reshapes U.S. Trade and Pharma Policy  altitudesmagazine.com
    5. Trump administration prepares 100% tariffs on some imported drugs  statnews.com

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  • Stocks Fall, Oil Jumps as Trump Says to Hit Iran: Markets Wrap

    Stocks Fall, Oil Jumps as Trump Says to Hit Iran: Markets Wrap

    (Bloomberg) — Stocks tumbled and oil jumped after President Donald Trump said the US would hit Iran extremely hard over the next two to three weeks, damping hopes for a swift resolution to the conflict.

    Asian shares reversed gains at the start Thursday, falling more than 1.4% and US equity-index futures retreated 1% as Trump spoke about the attacks in an address to the nation. Treasuries fell with the yield on the benchmark 10-year rising four basis points to 4.36%. Brent crude oil jumped 4.2% to above $105 a barrel.

    The core strategic objectives are nearing completion, Trump said from the White House. The president nevertheless suggested that military operations could soon escalate, saying “over the next two to three weeks, we’re going to bring them back to the stone ages where they belong.” But he also suggested diplomacy would continue, adding, “in the meantime, discussions are ongoing.”

    “President Trump’s speech did not contain what the market had hoped for — namely, indications of an end to the fighting,” said Jumpei Tanaka, head of investment strategy at Pictet Asset Management Japan. “Instead, he suggested a potential escalation of the situation, which is a clear negative for stocks.”

    The conflict in the Middle East has roiled financial markets and pushed several equity gauges into correction territory over the past five weeks. In the run-up to the speech, investor confidence had been building that a US scaling back of military action against Iran would help ease geopolitical tensions.

    Trump’s rare prime-time address came even as the Strait of Hormuz remained largely closed. The speech came as the president is grasping for an off-ramp in a conflict that has quickly slipped out of control.

    “Market is seemingly focusing on the idea that the war has not ended, the US is looking for escalation and hoping that will force Iran to make a deal,” said Rodrigo Catril, a currency strategist at National Australia Bank Ltd.

    Hours ahead of the speech, the Iranian president took the unusual step of issuing a letter addressed to Americans, arguing that his country has no enmity with the US and has acted in self-defense. He warned that “continuing along the path of confrontation is more costly and futile than ever before” and noted that attacks on infrastructure directly target the Iranian people.

    Earlier, Trump said that Iran has asked for a ceasefire, adding that the US would only consider it if the Strait of Hormuz was reopened. Iran’s foreign ministry said the claim of a ceasefire request was “false and baseless,” according to state TV.

    The latest back-and-forth follows separate comments from Trump on Tuesday when the president said he foresaw the US ending the conflict within two to three weeks, sparking a sharp rally in stocks.

    Meanwhile, some investors said it would take time for oil flows to return to normal even if the war ends within Trump’s timeframe, especially given the damage to some energy facilities. Trump’s team has also suggested that reopening the strait, which carries 20% of global crude, may not be necessary to end the hostilities.

    “Each passing week increases the global economic costs of the Iran conflict,” wrote Tiffany Wilding, economist at Pacific Investment Management Co. At some point, “the economic effects of persistent disruptions will start to build, with recessionary implications for the global economy.”

    Some of the main moves in markets:

    Stocks

    S&P 500 futures fell 0.8% as of 10:49 a.m. Tokyo time Japan’s Topix fell 0.9% Australia’s S&P/ASX 200 fell 0.5% Hong Kong’s Hang Seng fell 0.9% The Shanghai Composite fell 0.2% Euro Stoxx 50 futures fell 1.3% Currencies

    The Bloomberg Dollar Spot Index rose 0.3% The euro fell 0.3% to $1.1551 The Japanese yen fell 0.2% to 159.19 per dollar The offshore yuan fell 0.1% to 6.8867 per dollar Cryptocurrencies

    Bitcoin fell 1.5% to $67,125.35 Ether fell 2.3% to $2,094.81 Bonds

    The yield on 10-year Treasuries advanced four basis points to 4.36% Japan’s 10-year yield advanced 1.5 basis points to 2.315% Australia’s 10-year yield advanced 10 basis points to 5.01% Commodities

    West Texas Intermediate crude rose 3.5% to $103.65 a barrel Spot gold fell 1.2% to $4,699.39 an ounce This story was produced with the assistance of Bloomberg Automation.

    –With assistance from Momoka Yokoyama, Ruth Carson, Winnie Hsu, David Finnerty and Mark Cranfield.

    ©2026 Bloomberg L.P.

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  • The worst might not be over

    The worst might not be over

    Hello, this is Priyanka Salve, writing to you from Singapore.

    Welcome to the latest edition of "Inside India" — your one-stop destination for stories and developments from the world's fastest growing large economy.

    Indian markets have been rattled by the Iran war, with foreign investors fleeing and valuations slipping to rare lows. But fund managers tell me that low prices by themselves won't lure investors back.

    Enjoy!

    Any thoughts on today's newsletter? Share them with the team.

    The big story

    For months, trade tensions with the U.S. were dubbed the biggest overhang on Indian equities. When the two countries agreed on a trade pact in February, foreign investors poured nearly $2.5 billion into Indian stocks. But a month later, the market has completely reversed course.

    India's benchmark Nifty 50 fell more than 10% in March, as foreign investors sold over $12 billion in equities — the worst monthly sell-off on record.

    The index now trades at a price-to-earnings ratio of 19.6 times, a level rarely seen over the past decade. The only two occasions in the past ten years when Indian benchmark valuations dipped this low were during the early months of the Covid‑19 outbreak in 2020 and the Russia‑Ukraine war in 2022.

    So, I asked fund managers whether Indian markets are oversold — and whether these near-historically low valuations could be a good point to invest in the fabled "India growth story."

    A commuter cross a road in the rain on March 31, 2026 in New Delhi, India.

    Sanjeev Verma | Hindustan Times | Getty Images

    Indian economy under stress

    The escalating conflict in the Middle East has revealed that India "is structurally exposed," Pramod Gubbi, co-founder of portfolio management firm Marcellus Investment Managers, told me. If there is no quick resolution to the war and oil prices remain elevated, India's fiscal deficit, inflation, and currency will all come under pressure — which in turn will "affect demand and earnings," he said.

    Gubbi added that earnings growth in India has been weak for more than a year, and the current conflict will exacerbate it.

    Some of his concerns echo those raised by India's Chief Economic Advisor V. Anantha Nageswaran in a report published March 28.

    The world's fastest-growing economy's forecast of 7.0%–7.4% growth for the financial year ending March 2027 faces "considerable downside" risk due to rising energy costs and supply‑chain disruptions linked to the Iran war, Nageswaran warned. He also expects the trade deficit to "rise significantly" and lead to a "widening [of] the current account deficit."

    In response to these pressures, the Indian government introduced two key interventions last week. The first aimed to curb the falling rupee by limiting currency‑hedging positions that banks can take. The second was an excise duty cut on petrol and diesel to prevent a spike in retail fuel prices that could worsen inflation.

    While the rupee has strengthened thanks to the currency curbs, Nitin Jain, chief executive and director of Kotak Mahindra Asset Management Singapore, argued that keeping fuel prices artificially low for "even a quarter" could hurt government spending on "productive" activities like capex.

    Nomura in a note Monday estimated that a 10‑rupee‑per‑litre excise cut could have a total annual fiscal impact of 1.65 trillion rupees ($17.6 billion). "Higher subsidy requirements [fertilizer and fuel] and potential revenue shortfalls may widen the fiscal deficit, underscoring the need for expenditure prioritization," Nageswaran said.

    Such diversion of funds away from productive capex toward subsidies sends the wrong signal to foreign investors, Jain added.

    Fading growth

    While some of these issues are a significant overhang on the Indian markets, they could be transient if the Iran war ends sooner rather than later. The more stubborn worry with India is the lack of strong earnings growth.

    Earnings cuts reported between April and December 2025 "are the largest seen in the past four years," noted Indian brokerage Ambit Capital in a report shared with CNBC. Foreign investors, it said, will now focus "on earnings credibility," and lower valuations alone will not convince them to return.

    Indian markets have long commanded a valuation premium because businesses grew rapidly, supported by rising disposable incomes, job creation, and a consumption surge, experts said, adding that there are growing concerns among investors about this narrative.

    But today, net overseas direct investment into Indian businesses is languishing between $1 billion and $2 billion, according to data shared by Indian ratings and research firm Care Ratings on Tuesday. India's net FDI flows as a share of GDP are also significantly lower than those of Brazil and Vietnam, World Bank data shows.

    Experts say multinationals and foreign investors still want a share of India's consumption story — but the country's inability to create more white-collar jobs is undermining that narrative. According to a report by India's Azim University in mid-March, only a small share of graduates are securing "stable salaried jobs within a year of graduation."

    Consumption is a major driver of India's economy and a key magnet for foreign investment, but "without jobs, there won't be consumption," said Gubbi of Marcellus.

    Need to know

    India's telecom giant Bharti Airtel raises $1 billion for its data center arm from private equity firms
    Nxtra Data, Airtel's data center arm, will receive $435 million from Florida-headquartered Alpha Wave Global, $240 million from existing investor Washington-based Carlyle, and $35 million from New York City's Anchorage Capital.

    IndiGo names industry veteran William Walsh ‌as its new chief executive
    Walsh, 64, is currently the director general ‌of the International Air Transport Association and will join the Indian airline in early August. Walsh has served as the CEO of British Airways.

    India takes a 'huge hit' on tax revenue to keep fuel prices from surging during the Iran war
    The Indian government has cut central excise duties on petrol and diesel for domestic consumption by 10 rupees ($0.11) per liter each, to keep pump prices from rising as the Iran war disrupts global energy supplies. This will be a "huge hit" on the government's tax revenues, said Petroleum and Natural Gas Minister Hardeep Singh Puri.

    Coming up

    April 6: HSBC Composite final PMI for March

    April 8: RBI's monetary policy meeting

    Choose CNBC as your preferred source on Google and never miss a moment from the most trusted name in business news.

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  • Asian Stocks Rise on Hopes Iran War Nearing End: Markets Wrap

    Asian Stocks Rise on Hopes Iran War Nearing End: Markets Wrap

    (Bloomberg) — Asian equities extended their rebound as investors rotated back into stocks on optimism that the Iran war may be nearing a conclusion. Oil dropped.

    Stocks opened stronger in Japan and South Korea, sending the broader MSCI Asia Pacific Index up 0.5%. The moves came after the S&P 500 Index rose 0.7% Wednesday and the Nasdaq 100 advanced 1.2% on expectations that an end to the war will improve crude oil flows from the Middle East and support economic growth.

    Brent crude dropped more than 1% to trade around $100 a barrel, while an index of the dollar fell 0.1%.

    The broadly risk-on moves reflected easing concerns over a prolonged Middle East conflict, which has roiled financial markets and pushed several equity gauges into correction territory over the past five weeks. Investor focus will turn to President Donald Trump’s address to the nation at 9 p.m. Eastern Time, as confidence builds that the US may soon scale back its military action against Iran and help ease geopolitical tensions.

    “The sharp rally in stocks over the past 24 hours demonstrates how a resolution to the conflict, or hopes thereof, may quickly drive markets higher,” said Ulrike Hoffmann-Burchardi at UBS Global Wealth Management. “We continue to believe global stock markets will end the year higher than they are today.”

    In other corners of the market, gold built on its gains to trade just under $4,800 an ounce. Treasuries registered a lumpy session with the 10-year ending Wednesday little changed, its 30-year equivalent rallying and the two-year edging lower following solid data on the US labor market and retail sales.

    Trump is scheduled to deliver a rare prime-time address even as the Strait of Hormuz remains largely closed. The US leader is expected to hail his military campaign in Iran as a success and stress that the conclusion of operations may come in two to three weeks, according to a White House official.

    Hours ahead of that speech, the Iranian president took the unusual step of issuing a letter addressed to Americans, arguing that his country has no enmity with the US and has acted in self-defense. He warned that “continuing along the path of confrontation is more costly and futile than ever before” and noted that attacks on infrastructure directly target the Iranian people.

    Trump said on Wednesday that Iran has asked for a ceasefire, adding that the US would only consider it if the Strait of Hormuz was reopened. Iran’s foreign ministry said the claim of a ceasefire request was “false and baseless,” according to state TV.

    The latest back-and-forth follows separate comments from Trump on Tuesday when the president said he foresaw the US ending the conflict within two to three weeks, sparking a sharp rally in stocks.

    Elsewhere, tariff concerns resurfaced as the Trump administration prepares a 25% levy on finished goods made with imported steel and aluminum, according to the Wall Street Journal.

    In corporate news, KKR & Co.’s non-traded business development company KKR FS Income Trust, a type of private credit fund for retail investors, curbed redemptions after receiving an increase in such requests, according to a shareholder letter.

    Meanwhile, some investors said it would take time for oil flows to return to normal even if the war ends within Trump’s timeframe, especially given the damage to some energy facilities. Trump’s team has also suggested that reopening the strait, which carries 20% of global crude, may not be necessary to end the hostilities.

    “Each passing week increases the global economic costs of the Iran conflict,” wrote Tiffany Wilding, economist at Pacific Investment Management Co. At some point, “the economic effects of persistent disruptions will start to build, with recessionary implications for the global economy.”

    Some of the main moves in markets:

    Stocks

    S&P 500 futures were little changed as of 9:02 a.m. Tokyo time Hang Seng futures were little changed Japan’s Topix rose 1% Australia’s S&P/ASX 200 rose 0.5% Euro Stoxx 50 futures rose 3% Currencies

    The Bloomberg Dollar Spot Index was little changed The euro was little changed at $1.1590 The Japanese yen was little changed at 158.69 per dollar The offshore yuan was unchanged at 6.8774 per dollar The Australian dollar was little changed at $0.6922 Cryptocurrencies

    Bitcoin fell 0.1% to $68,101.43 Ether fell 0.2% to $2,139.71 Bonds

    The yield on 10-year Treasuries was little changed at 4.32% Australia’s 10-year yield advanced five basis points to 4.96% Commodities

    West Texas Intermediate crude fell 1.4% to $98.72 a barrel Spot gold rose 0.5% to $4,780.80 an ounce This story was produced with the assistance of Bloomberg Automation.

    ©2026 Bloomberg L.P.

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  • Kirkland Advises Zendesk on Acquisition of Forethought | News

    Kirkland & Ellis advised Zendesk on its acquisition of Forethought, an AI agent platform enabling Zendesk to immediately offer self-improving AI agents to customers looking to elevate their service experiences. Following the completion of the acquisition, Zendesk will rapidly integrate Forethought’s AI technology, setting a new standard for how autonomous agents are deployed at scale.

    Read Zendesk’s press release

    The Kirkland team included corporate lawyers Abhishek Kolay, Natasha Shah and Oseremen Eromosele; executive compensation lawyers Rohit Nafday and Paige Costakos; technology & IP transactions lawyers Matthew Lovell, Amber Harezlak and Abby O’Neill; tax lawyers Jared Rusman and Claire Oxford; employee benefits lawyer Alexandra Mihalas; employment & labor lawyer Risa Salins; and antitrust & competition lawyer Stephanie Greco.

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  • Gene editing therapy shows success against severe sickle cell disease – Medical Xpress

    1. Gene editing therapy shows success against severe sickle cell disease  Medical Xpress
    2. Base-Editing Gene Therapy Shows Promise in Sickle Cell Disease  MedPage Today
    3. Beam Therapeutics Announces Publication of BEACON Phase 1/2 Data for risto-cel in Patients with Sickle Cell Disease (SCD) in The New England Journal of Medicine  The Manila Times
    4. Beam Therapeutics publishes sickle cell therapy trial data  investing.com
    5. In 31 sickle cell patients, Beam saw no severe pain crises after risto-cel  Stock Titan

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  • TransUnion Completes Acquisition of the Mobile Division of RealNetworks

    TransUnion Completes Acquisition of the Mobile Division of RealNetworks

    TransUnion remains committed to fostering innovation within the telecommunications sector and enabling secure, trusted interactions between businesses and consumers,” said Mohamed Abdelsadek, Chief Global Solutions Officer, TransUnion. “As the digital landscape rapidly evolves, we are strengthening our solutions for businesses seeking reliable, scalable messaging.”

    “For more than 20 years, our mobile team has developed innovative products that enable trusted communications worldwide,” said Rob Glaser, Chairman and Chief Executive Officer, RealNetworks Group. “We are grateful to our many customers and partners for their support. I also want to deeply thank the Real Mobile team members who are now joining the TransUnion team.”

    TransUnion’s Trusted Call Solutions have improved outbound calling by increasing contact rates, enriching customer experience with additional context, blocking fraudulent calls, and confirming call authentication. With the addition of RealNetworks’ cutting-edge telecom platform, TransUnion plans to offer a broader suite of voice, messaging and analytics tools that help businesses more effectively communicate with their customers.

    “We expect integrating RealNetworks’ mobile capabilities with Trusted Call Solutions will allow TransUnion to deliver a comprehensive, identity-anchored omnichannel engagement platform,” added James Garvert, SVP of Communications Solutions, TransUnion. “We look forward to providing more seamless, secure communications across both voice and messaging channels to help consumers and businesses connect with greater confidence.”

    The terms of the transaction have not been disclosed. The transaction was funded with existing cash-on-hand and is not expected to have a material impact on leverage, liquidity or TransUnion’s 2026 operating results.

    About TransUnion (NYSE: TRU)

    TransUnion is a global information and insights company with over 13,000 associates operating in more than 30 countries. We make trust possible by ensuring each person is reliably represented in the marketplace. We do this with a Tru™ picture of each person: an actionable view of consumers, stewarded with care. Through our acquisitions and technology investments we have developed innovative solutions that extend beyond our strong foundation in core credit into areas such as marketing, fraud, risk and advanced analytics. As a result, consumers and businesses can transact with confidence and achieve great things. We call this Information for Good® — and it leads to economic opportunity, great experiences and personal empowerment for millions of people around the world. http://www.transunion.com/business

    About RealNetworks

    Building on 30+ years of digital media innovation, RealNetworks creates AI-powered products that enhance and secure our daily lives. Real’s portfolio includes: SAFR®, a unified computer vision platform for enterprise security and access control; GameHouse®, a mobile games business delivering great games for women; and RealPlayer®, the iconic media player reimagined with AI. Learn more at www.realnetworks.com

    TransUnion Forward-Looking Statements

     This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements are based on the current beliefs and expectations of TransUnion’s management and are subject to significant risks and uncertainties, many of which are beyond our control. Actual results may differ materially from those described in the forward-looking statements. Any statements made in this press release that are not statements of historical fact, including statements about our beliefs and expectations, are forward-looking statements. Forward-looking statements include information concerning anticipated benefits of the transaction, including strategic, business and anticipated benefits to our results of operations and descriptions of our business plans, prospects and strategies.

    Factors that could cause actual results to differ materially from those described in the forward-looking statements include: failure to realize the synergies and other benefits expected from the acquisition of the mobile division of RealNetworks the possibility that the acquisition, including the integration of the mobile division of RealNetworks, may be more costly to complete than anticipated; business disruption following the acquisition closing; potential business uncertainty, including adverse reactions or changes to business relationships resulting from the completion of the acquisition; the effects of pending and future legislation and regulatory actions and reforms; macroeconomic and industry trends and adverse developments in the telecommunications software and services, debt, consumer credit and financial services markets and other macroeconomic factors beyond TransUnion’s control; risks related to TransUnion’s indebtedness, including our ability to make timely payments on principal and interest and our ability to satisfy covenants in the agreements governing our indebtedness; and other one-time events and other factors, including those found in our Annual Report on Form 10-K for the year ended December 31, 2025, and any subsequent Annual Report on Form 10-K, Quarterly Report on Form 10-Q or Current Report on Form 8-K, which are filed with the Securities and Exchange Commission and are available on TransUnion’s website. You should evaluate all forward-looking statements made in this press release in the context of these risks and uncertainties. The forward-looking statements contained in this press release speak only as of the date of this press release. We undertake no obligation to publicly release the result of any revisions to these forward-looking statements to reflect the impact of events or circumstances that may arise after the date of this press release.

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